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PKZ, a Fish-Unique eIF2 alpha Kinase Involved in Innate Immune Response
Wu, Chuxin1; Zhang, Yibing2; Hu, Chengyu3
2020-03-31
Source PublicationFRONTIERS IN IMMUNOLOGY
ISSN1664-3224
Volume11Issue:1Pages:6
Abstract

PKZ is a novel and unique eIF2 alpha protein kinase identified in fish. Although PKZ is most homologous to PKR, particularly in the C-terminal catalytic domain, it contains two N-terminal Z-DNA-binding domains (Z alpha 1 and Z alpha 2) instead of the dsRNA binding domains (dsRBDs) in PKR. As a novel member of eIF2 alpha kinase family, the available data suggest that PKZ has some distinct mechanisms for recognition, binding, and B-Z DNA transition. Functionally, PKZ seems to be activated by the binding of Z alpha to Z-DNA and participates in innate immune responses. In this review, we summarize the recent progress on fish PKZ.

KeywordPKZ Z alpha domain Z-DNA kinase activity fish
DOI10.3389/fimmu.2020.00585
Indexed BySCI
Language英语
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000526856900001
WOS KeywordZ-DNA-BINDING ; DEPENDENT PROTEIN-KINASE ; Z-ALPHA DOMAIN ; HUMAN EDITING ENZYME ; B-Z TRANSITION ; FUNCTIONAL-ANALYSIS ; MOLECULAR-CLONING ; TRANSLATION INITIATION ; CRYSTAL-STRUCTURE ; EXPRESSION
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/36098
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorZhang, Yibing; Hu, Chengyu
Affiliation1.Yuzhang Normal Univ, Dept Nat Sci, Nanchang, Jiangxi, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
3.Nanchang Univ, Coll Life Sci, Dept Biosci, Nanchang, Jiangxi, Peoples R China
Recommended Citation
GB/T 7714
Wu, Chuxin,Zhang, Yibing,Hu, Chengyu. PKZ, a Fish-Unique eIF2 alpha Kinase Involved in Innate Immune Response[J]. FRONTIERS IN IMMUNOLOGY,2020,11(1):6.
APA Wu, Chuxin,Zhang, Yibing,&Hu, Chengyu.(2020).PKZ, a Fish-Unique eIF2 alpha Kinase Involved in Innate Immune Response.FRONTIERS IN IMMUNOLOGY,11(1),6.
MLA Wu, Chuxin,et al."PKZ, a Fish-Unique eIF2 alpha Kinase Involved in Innate Immune Response".FRONTIERS IN IMMUNOLOGY 11.1(2020):6.
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