IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Grass carp reovirus VP56 represses interferon production by degrading phosphorylated IRF7
Zhang, Can1,3; Lu, Long-Feng1; Li, Zhuo-Cong1,3; Zhou, Xiao-Yu1,3; Zhou, Yu1,3; Chen, Dan-Dan1; Li, Shun1; Zhang, Yong-An1,2
2020-04-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume99Issue:1Pages:99-106
Abstract

Grass carp reovirus (GCRV) is an efficient pathogen causing high mortality in grass carp, meanwhile, fish interferon (IFN) is a powerful cytokine enabling host cells to establish an antiviral state; therefore, the strategies used by GCRV to escape the cellular IFN response need to be investigated. Here, we report that GCRV VP56 inhibits host IFN production by degrading the transcription factor IFN regulatory factor 7 (IRF7). First, overexpression of VP56 inhibited the IFN production induced by the polyinosinic-polycytidylic acid (poly I:C) and mitochondrial antiviral signaling protein (MAVS), while the capacity of IRF7 on IFN induction was unaffected. Second, VP56 interacted with RLRs but did not affect the stabilization of the proteins in the normal state, while the phosphorylated IRF7 activated by TBK1 was degraded by VP56 through K48-linked ubiquitination. Finally, overexpression of VP56 remarkably reduced the host cellular ifn transcription and facilitated viral proliferation. Taken together, our results demonstrate that GCRV VP56 suppresses the host IFN response by targeting phosphorylated IRF7 for ubiquitination and degradation.

KeywordVP56 GCRV Immune evasion IRF7 Interferon
DOI10.1016/j.fsi.2020.02.004
Indexed BySCI
Language英语
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000523601500011
WOS KeywordANTIVIRAL SIGNALING PROTEIN ; COMPLETE GENOME SEQUENCE ; INNATE IMMUNE-RESPONSE ; PATHOGEN RECOGNITION ; ADAPTER PROTEIN ; VIRUS ; GENE ; IDENTIFICATION ; EXPRESSION ; INDUCTION
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/36074
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorLi, Shun; Zhang, Yong-An
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Huazhong Agr Univ, Coll Fisheries, State Key Lab Agr Microbiol, Wuhan, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Can,Lu, Long-Feng,Li, Zhuo-Cong,et al. Grass carp reovirus VP56 represses interferon production by degrading phosphorylated IRF7[J]. FISH & SHELLFISH IMMUNOLOGY,2020,99(1):99-106.
APA Zhang, Can.,Lu, Long-Feng.,Li, Zhuo-Cong.,Zhou, Xiao-Yu.,Zhou, Yu.,...&Zhang, Yong-An.(2020).Grass carp reovirus VP56 represses interferon production by degrading phosphorylated IRF7.FISH & SHELLFISH IMMUNOLOGY,99(1),99-106.
MLA Zhang, Can,et al."Grass carp reovirus VP56 represses interferon production by degrading phosphorylated IRF7".FISH & SHELLFISH IMMUNOLOGY 99.1(2020):99-106.
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