IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Molecular and functional characterization of tilapia DDX41 in IFN regulation
Gan, Zhen1,2,3,4,5; Cheng, Jun1,3,4; Hou, Jing1,2,3,4,5; Xia, Hongli1,3,4; Chen, Wenjie1,2,3,4,5; Xia, Liqun1,3,4; Nie, Pin2,6; Lu, Yishan1,3,4
2020-04-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume99Issue:1Pages:386-391
Abstract

DEAD-box helicase 41 (DDX41) is a key cytosolic DNA sensor playing critical roles in the regulation of type I IFN responses, and their functions have been well-characterized in mammals. However, little information is available regarding the function of fish DDX41. In this study, a DDX41 gene, named On-DDX41, was identified in Nile tilapia, Oreochromis niloticus. The predicted protein of On-DDX41 contains several structural features known in DDX41, including conserved DEADc and HELICc domains, and a conserved sequence "Asp-Glu-Ala-Asp (D-E-A-D)". On-DDX41 gene was constitutively expressed in all tissues examined, with the highest expression level observed in liver and muscle, and was inducible after poly(I:C) stimulation. Moreover, the overexpression of On-DDX41 can elicit a strong activation of both zebrafish IFN1 and IFN3 promoter in fish cells treated with poly (dA:dT). The present study thus contributes to a better understanding of the functional properties of DDX41 in fish.

KeywordOreochromis niloticus DDX41 Cytosolic DNA sensors Type I interferon Promoter activity
DOI10.1016/j.fsi.2020.02.031
Indexed BySCI
Language英语
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000523601500040
WOS KeywordOREOCHROMIS-NILOTICUS ; IMMUNE-RESPONSE ; I IFNS ; CYTOSOLIC SENSOR ; EXPRESSION ; INTERFERONS ; RECEPTORS ; INNATE ; EVOLUTION ; INSIGHTS
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/36052
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorNie, Pin; Lu, Yishan
Affiliation1.Guangdong Ocean Univ, Shenzhen Inst, 3 Binhai 2nd Rd, Shenzhen 518120, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
3.Guangdong Ocean Univ, Coll Fishery, Zhanjiang 524025, Peoples R China
4.Shenzhen Publ Serv Platform Evaluat Marine Econ A, Guangdong Prov Engn Res Ctr Aquat Anim Hlth Asses, Shenzhen 518120, Peoples R China
5.Shenzhen Dapeng New Dist Sci & Technol Innovat Se, Shenzhen 518120, Peoples R China
6.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Gan, Zhen,Cheng, Jun,Hou, Jing,et al. Molecular and functional characterization of tilapia DDX41 in IFN regulation[J]. FISH & SHELLFISH IMMUNOLOGY,2020,99(1):386-391.
APA Gan, Zhen.,Cheng, Jun.,Hou, Jing.,Xia, Hongli.,Chen, Wenjie.,...&Lu, Yishan.(2020).Molecular and functional characterization of tilapia DDX41 in IFN regulation.FISH & SHELLFISH IMMUNOLOGY,99(1),386-391.
MLA Gan, Zhen,et al."Molecular and functional characterization of tilapia DDX41 in IFN regulation".FISH & SHELLFISH IMMUNOLOGY 99.1(2020):386-391.
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