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The genome of the marine rotifer Brachionus koreanus sheds light on the antioxidative defense system in response to 2-ethyl-phenanthrene and piperonyl butoxide
Park, Jun Chul1; Choi, Beom-Soon2; Kim, Min-Sub1; Shi, Huahong3; Zhou, Bingsheng4; Park, Heum Gi5; Lee, Jae-Seong1
2020-04-01
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume221Issue:1Pages:15
Abstract

Brachionus: spp. (Rotifera: Monogononta) have been introduced as ecotoxicological model-organisms that are widely distributed in aquatic environments. Among the Brachionus spp., the monogonont rotifer Brachionus koreanus has been widely used for ecology, ecotoxicology, and evolution, thus, providing the whole genome data of B. koreanus is important for further understandings of in-depth molecular mechanisms. In this study, the completed assembly and characterization of the B. koreanus genome resulted in a total length of 85.7 Mb with 14,975 annotated genes. The final number of scaffolds was 567 with an N50 value and a GC content of 1.86 Mb and 24.35 %, respectively. Based on the fully constructed genome database, a total of 24 CYPs, 23 GSTs, two SODs, and a single CAT genes were identified and analyzed antioxidant activities (CAT, SOD, and GST), and transcriptional regulation of the entire CYPs, GSTs, SODs, and CAT in response to 2-ethyl-phenanthrene (2-ethyl-PHE) and piperonyl butoxide (PBO), to demonstrate the usefulness of the whole genome library of B. koreanus in response xenobiotic-induced oxidative stress. The assembled B. koreanus genome will provide a better understanding on the molecular ecotoxicology in the view of molecular mechanisms underlying toxicological responses, particularly on xenobiotic detoxification processes in the rotifer B. koreanus.

KeywordRotifer Genome Detoxification mechanism Polycyclic aromatic hydrocarbon Piperonyl butoxide
DOI10.1016/j.aquatox.2020.105443
Indexed BySCI
Language英语
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS SubjectMarine & Freshwater Biology ; Toxicology
WOS IDWOS:000526050100017
WOS KeywordPOLYCYCLIC AROMATIC-HYDROCARBONS ; LIFE-CYCLE PARAMETERS ; OXIDATIVE STRESS ; CYTOCHROME-P450 GENES ; WIDE IDENTIFICATION ; SIGNALING PATHWAY ; CRUDE-OIL ; TOXICITY ; EXPRESSION ; WATER
PublisherELSEVIER
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/36018
Collection其他_期刊论文
Corresponding AuthorLee, Jae-Seong
Affiliation1.Sungkyunkwan Univ, Coll Sci, Dept Biol Sci, Suwon 16419, South Korea
2.Phyzen Genom Inst, Seongnam 13558, South Korea
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
4.East China Normal Univ, State Key Lab Estuarine & Coastal Res, Shanghai 200241, Peoples R China
5.Gangneung Wonju Natl Univ, Coll Life Sci, Dept Marine Resource Dev, Kangnung 25457, South Korea
Recommended Citation
GB/T 7714
Park, Jun Chul,Choi, Beom-Soon,Kim, Min-Sub,et al. The genome of the marine rotifer Brachionus koreanus sheds light on the antioxidative defense system in response to 2-ethyl-phenanthrene and piperonyl butoxide[J]. AQUATIC TOXICOLOGY,2020,221(1):15.
APA Park, Jun Chul.,Choi, Beom-Soon.,Kim, Min-Sub.,Shi, Huahong.,Zhou, Bingsheng.,...&Lee, Jae-Seong.(2020).The genome of the marine rotifer Brachionus koreanus sheds light on the antioxidative defense system in response to 2-ethyl-phenanthrene and piperonyl butoxide.AQUATIC TOXICOLOGY,221(1),15.
MLA Park, Jun Chul,et al."The genome of the marine rotifer Brachionus koreanus sheds light on the antioxidative defense system in response to 2-ethyl-phenanthrene and piperonyl butoxide".AQUATIC TOXICOLOGY 221.1(2020):15.
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