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Evaluation and mechanistic study of chlordecone-induced thyroid disruption: Based on in vivo, in vitro and in silico assays
Yang, Lihua1; Zha, Jinmiao2,3; Guo, Yongyong1; Zhou, Bingsheng1
Corresponding AuthorZha, Jinmiao(jmzha@rcees.ac.cn)
2020-05-10
Source PublicationSCIENCE OF THE TOTAL ENVIRONMENT
ISSN0048-9697
Volume716Pages:9
AbstractThe present study aimed to evaluate the thyroid-disrupting potency of chlordecone, and reveal the underlying mechanism. In the in vivo assays, rare minnow embryos were exposed to 0, 0.01, 0.1, 1 and 10 mu g.L-1 chlordecone until sexually mature. The results showed decreased T4 but increased T3 concentrations in plasma, upregulated mRNA levels of thyrotropin-releasing hormone receptor (n hr) and sodium-iodide symporter (nis) in the brain, and transthyretin (ttr), thyroid hormone receptor alpha (tr alpha) and deiodinase enzymes (dio1 and dio2) in the liver of adult fish. In the in vitro assays, single chlordecone treatments promoted growth hormone (GH) and prolactin (PRL) secretion in GH3 cells. Transcription of thyroid receptor (tr beta) was inhibited, but this is not likely responsible for chlordecone-induced GH secretion and altered transcription. When co-treated with T3, chlordecone acted independently of the effect of T3 on GH secretion: chlordecone-induced GH/PRL secretion and mRNA expression were further promoted when co-treated with E2, but inhibited when co-treated with ICE indicating an important role for estrogen receptors (ERs) in chlordecone-induced changes in GH3 cells. Further-more, in silico prediction suggested no stable interactions between chlordecone and thyroid hormone-related proteins, as well as a regulatory role for ERs in thyroid systems. Overall, our results indicated that chlordecone may have adverse effects on thyroid systems upon long-term exposure. However, rather of TRs, ERs may be responsible for thyroid disruption following chlordecone exposure. (C) 2020 Elsevier B.V. All rights reserved.
KeywordChlordecone Thyroid disruption Rare minnow GH3 cells Estrogen receptor
DOI10.1016/j.scitotenv.2020.136987
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2018YFD0900701] ; National S&T BasicWork of China[2014FY120200]
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000519987300064
WOS KeywordPOLYBROMINATED DIPHENYL ETHERS ; MESSENGER-RNA EXPRESSION ; ENDOCRINE DISRUPTION ; HORMONE-ACTIVITY ; EXPOSURE ; ESTROGEN ; TRANSCRIPTION ; EPIDEMIOLOGY ; RECEPTORS ; CHEMICALS
PublisherELSEVIER
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/35987
Collection水环境工程研究中心_期刊论文
Corresponding AuthorZha, Jinmiao
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Drinking Water Sci & Technol, Beijing 100085, Peoples R China
3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing Key Lab Ind Wastewater Treatment & Reuse, Beijing 100085, Peoples R China
Recommended Citation
GB/T 7714
Yang, Lihua,Zha, Jinmiao,Guo, Yongyong,et al. Evaluation and mechanistic study of chlordecone-induced thyroid disruption: Based on in vivo, in vitro and in silico assays[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2020,716:9.
APA Yang, Lihua,Zha, Jinmiao,Guo, Yongyong,&Zhou, Bingsheng.(2020).Evaluation and mechanistic study of chlordecone-induced thyroid disruption: Based on in vivo, in vitro and in silico assays.SCIENCE OF THE TOTAL ENVIRONMENT,716,9.
MLA Yang, Lihua,et al."Evaluation and mechanistic study of chlordecone-induced thyroid disruption: Based on in vivo, in vitro and in silico assays".SCIENCE OF THE TOTAL ENVIRONMENT 716(2020):9.
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