IHB OpenIR  > 藻类生物学及应用研究中心  > 期刊论文
Synergistic toxicity of microcystin-LR and Cu to zebrafish (Danio rerio)
Wei, Huimin1,2; Wang, Shao3; Xu, Elvis Genbo4,5; Liu, Jin6; Li, Xi3; Wang, Zhi1
Corresponding AuthorLi, Xi(xili_ihb@126.com) ; Wang, Zhi(zwang@whigg.ac.cn)
2020-04-15
Source PublicationSCIENCE OF THE TOTAL ENVIRONMENT
ISSN0048-9697
Volume713Pages:9
AbstractToxic cyanobacterial blooms often coincide with metal pollution in a freshwater environment because of surface run-off enriched with nutrients and metals. However, the joint toxic effects of cyanobacterial toxins and metals on aquatic animals remain unknown. In this study, single and joint toxic effects and mechanisms of microcystinLR (MCLR) and copper (Cu) were investigated in the early development of zebrafish (Danio rerio). The LC50(72)(-h) values were 2.79 mg/L for MCLR and 3.23 mg/L for Cu. The sublethal concentrations of MCLR (<= 600 mu g/L) did not affect the normal development of zebrafish but increased its hatchability. Strong synergistic toxic effects were observed after co-exposure to MCLR and Cu at environmental concentrations (<= 60 mu g/L). The synergistic toxic effects of these two compounds could be attributed to the increased bioaccumulation of MCLR and Cu, which was mediated by MCLR transporters (e.g., oatp1d1 and oatp2b1) and Cu transporters (e.g., ctr1 and atp7a), in zebrafish. Such bioaccumulation caused oxidative stress, as suggested by the disrupted gene expression of anti-oxidative enzymes (e.g., Cu/Zn-SOD, Mn-SOD, and CAT). Our results revealed for the first time the synergistic toxic effects and potential toxic mechanism of MCLR-Cu in aquatic animals. These synergistic effects should be considered when assessing the ecological risk of toxic cyanobacterial blooms. (C) 2019 Published by Elsevier B.V.
KeywordJoint effect Microcystin Copper Zebrafish Gene expression
DOI10.1016/j.scitotenv.2019.136393
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[NSFC: 41601545] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[2018369]
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000514544700134
WOS KeywordOXIDATIVE STRESS ; ANTIOXIDANT ENZYMES ; INDUCED APOPTOSIS ; COPPER ; LAKE ; CYANOBACTERIA ; RESPONSES ; FISH ; BIOACCUMULATION ; IDENTIFICATION
PublisherELSEVIER
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/35953
Collection藻类生物学及应用研究中心_期刊论文
Corresponding AuthorLi, Xi; Wang, Zhi
Affiliation1.Chinese Acad Sci, Innovat Acad Precis Measurement Sci & Technol, Inst Geodesy & Geophys, Key Lab Environm & Disaster Monitoring & Evaluat, Wuhan 430077, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Wenzhou Med Univ, Affiliated Kangning Hosp, Wenzhou 325000, Zhejiang, Peoples R China
4.McGill Univ, Dept Chem Engn, 3610 Univ St, Montreal, PQ H3A 0C5, Canada
5.Univ Southern Denmark, Dept Biol, DK-5230 Odense, Denmark
6.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Wei, Huimin,Wang, Shao,Xu, Elvis Genbo,et al. Synergistic toxicity of microcystin-LR and Cu to zebrafish (Danio rerio)[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2020,713:9.
APA Wei, Huimin,Wang, Shao,Xu, Elvis Genbo,Liu, Jin,Li, Xi,&Wang, Zhi.(2020).Synergistic toxicity of microcystin-LR and Cu to zebrafish (Danio rerio).SCIENCE OF THE TOTAL ENVIRONMENT,713,9.
MLA Wei, Huimin,et al."Synergistic toxicity of microcystin-LR and Cu to zebrafish (Danio rerio)".SCIENCE OF THE TOTAL ENVIRONMENT 713(2020):9.
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