| Effect of the complete replacement of dietary fish meal by soybean meal on histopathology and immune response of the hindgut in grass carp (Ctenopharyngodon idellus) | |
| Peng, Kai-Song1,2; Wu, Nan1; Cui, Zheng-Wei1,3; Zhang, Xiang-Yang1,3; Lu, Xiao-Bing1,3; Wang, Zhao-Xi1,3; Chen, Dan-Dan1; Zhang, Yong-An1 | |
| Corresponding Author | Peng, Kai-Song(kaisongpeng@ahau.edu.cn) |
| 2020-03-01 | |
| Source Publication | VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
 |
| ISSN | 0165-2427 |
| Volume | 221Pages:9 |
| Abstract | A 14-day experiment was conducted to explore the pathological process and immune response of soybean meal (SBM) induced enteritis (SBMIE) in grass carp (Ctenopharyngodon idellus). The complete replacement of dietary fish meal (FM) with SBM resulted in a remarkable reduction in final body weight, weight gain ratio, and feed conversion efficiency (p < 0.05). The typical histopathological changes of SBMIE appeared starting at day 4, and progressively increased in severity until day 8, then gradually subsided after day 11. The course of SBMIE could be divided into incubation period (days 1-2), prodromal period (days 3-6), symptomatic period (days 7-10), and convalescent period (days 11-14). Transcription levels of pro-inflammatory cytokines, including IL-1 beta, TNF-alpha, IL-6, IL-8, IL-17A/F1 and IFN-gamma 2, were up-regulated during the prodromal period, and then down-regulated during the convalescent period. Transcript levels of anti-inflammatory cytokines (IL-10 and TGF beta 1) and their receptors (IL-10RI and T beta RII), were up-regulated during the prodromal and convalescent periods. Transcript levels of MHCII beta, lg mu, Ig tau, TCR delta, TCR beta, CD4, and CD8 alpha were altered in SBMIE. Furthermore, expression levels of T-bet, IFN-gamma 2, ROR gamma 2 and IL-17A/F1 were significantly increased in the initiation of enteritis, whereas the transcript levels of Foxp3 and IL-2/15Ra were significantly up-regulated in the repair of enteritis. In conclusion, grass carp SBMIE is regulated by the adjustment of SBM-based diet intake, and the changes of the above-mentioned genes expression suggest that these genes may be involved in SBMIE. |
| Keyword | Grass carp Enteritis Histopathology IL-17A/F1 IL-2/15Ra Ig tau |
| DOI | 10.1016/j.vetimm.2020.110009 |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[31472307] ; Anhui Provincial Modern Agro-industry Technology Research System[NYCYTX-2016-84] |
| WOS Research Area | Immunology ; Veterinary Sciences |
| WOS Subject | Immunology ; Veterinary Sciences |
| WOS ID | WOS:000521113500001 |
| WOS Keyword | SALMON SALMO-SALAR ; ATLANTIC SALMON ; INDUCED ENTERITIS ; DISTAL INTESTINE ; GENE-EXPRESSION ; L. ; ENTEROPATHY ; REACTIVITY ; MARKERS ; HEALTH |
| Publisher | ELSEVIER |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System ; Anhui Provincial Modern Agro-industry Technology Research System |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/35919 |
| Collection | 水生生物分子与细胞生物学研究中心_期刊论文 |
| Corresponding Author | Peng, Kai-Song |
| Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, 7 Donghu South Rd, Wuhan 430072, Hubei, Peoples R China 2.Anhui Agr Univ, Coll Anim Sci & Technol, 130 Changjiang West Rd, Hefei 230036, Anhui, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Peng, Kai-Song,Wu, Nan,Cui, Zheng-Wei,et al. Effect of the complete replacement of dietary fish meal by soybean meal on histopathology and immune response of the hindgut in grass carp (Ctenopharyngodon idellus)[J]. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,2020,221:9. |
| APA | Peng, Kai-Song.,Wu, Nan.,Cui, Zheng-Wei.,Zhang, Xiang-Yang.,Lu, Xiao-Bing.,...&Zhang, Yong-An.(2020).Effect of the complete replacement of dietary fish meal by soybean meal on histopathology and immune response of the hindgut in grass carp (Ctenopharyngodon idellus).VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,221,9. |
| MLA | Peng, Kai-Song,et al."Effect of the complete replacement of dietary fish meal by soybean meal on histopathology and immune response of the hindgut in grass carp (Ctenopharyngodon idellus)".VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 221(2020):9. |
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