IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish
Ren, Fan1; Lin, Qiaohong1; Gong, Gaorui1; Du, Xian2,3; Dan, Hong1; Qin, Wenying2,3; Miao, Ran1; Xiong, Yang1; Xiao, Rui2,3; Li, Xiaohui1; Gui, Jian-Fang1,4; Mei, Jie1
2020-03-03
Source PublicationCOMMUNICATIONS BIOLOGY
Volume3Issue:1Pages:10
Abstract

Early embryogenesis relies on maternally inherited mRNAs. Although the mechanism of maternal mRNA degradation during maternal-to-zygotic transition (MZT) has been extensively studied in vertebrates, how the embryos maintain maternal mRNA stability remains unclear. Here, we identify Igf2bp3 as an important regulator of maternal mRNA stability in zebrafish. Depletion of maternal igf2bp3 destabilizes maternal mRNAs prior to MZT and leads to severe developmental defects, including abnormal cytoskeleton organization and cell division. However, the process of oogenesis and the expression levels of maternal mRNAs in unfertilized eggs are normal in maternal igf2bp3 mutants. Gene ontology analysis revealed that these functions are largely mediated by Igf2bp3-bound mRNAs. Indeed, Igf2bp3 depletion destabilizes while its overexpression enhances its targeting maternal mRNAs. Interestingly, igf2bp3 overexpression in wild-type embryos also causes a developmental delay. Altogether, these findings highlight an important function of Igf2bp3 in controlling early zebrafish embryogenesis by binding and regulating the stability of maternal mRNAs. In early embryogenesis, maternal mRNAs are degraded at the maternal-to-zygotic transition (MZT). Mei et al find that the stability of maternal mRNAs before MZT is maintained by the mRNA binding protein Igf2bp3, which is also required for normal zebrafish development.

DOI10.1038/s42003-020-0827-2
Indexed BySCI
Language英语
WOS Research AreaLife Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics
WOS SubjectBiology ; Multidisciplinary Sciences
WOS IDWOS:000518989000002
WOS KeywordTO-ZYGOTIC TRANSITION ; FILAMENTOUS ACTIN ; BUCKY BALL ; MYOSIN-II ; GENE ; TRANSCRIPTOME ; CLEARANCE ; CYTOSKELETON ; TRANSLATION ; PACKAGE
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/35822
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorMei, Jie
Affiliation1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
2.Wuhan Univ, Zhongnan Hosp, Med Res Inst, Frontier Sci Ctr Immunol & Metab, Wuhan 430071, Peoples R China
3.Wuhan Univ, Zhongnan Hosp, Dept Hematol, Wuhan 430071, Peoples R China
4.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Ren, Fan,Lin, Qiaohong,Gong, Gaorui,et al. Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish[J]. COMMUNICATIONS BIOLOGY,2020,3(1):10.
APA Ren, Fan.,Lin, Qiaohong.,Gong, Gaorui.,Du, Xian.,Dan, Hong.,...&Mei, Jie.(2020).Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish.COMMUNICATIONS BIOLOGY,3(1),10.
MLA Ren, Fan,et al."Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish".COMMUNICATIONS BIOLOGY 3.1(2020):10.
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