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题名: Complete genome sequence analysis of the fish pathogen Flavobacterium columnare provides insights into antibiotic resistance and pathogenicity related genes
作者: Zhang, Yulei1; Zhao, Lijuan1, 2; Chen, Wenjie2; Huang, Yunmao2; Yang, Ling2; Sarathbabu, V.2; Wu, Zaohe2; Li, Jun2, 4, 5; Nie, Pin3; Lin, Li1, 2, 5, 6
关键词: Flavobacterium columnare ; Complete genome ; Antibiotic resistance genes ; Pathogenicity related genes
刊名: MICROBIAL PATHOGENESIS
发表日期: 2017-10-01
DOI: 10.1016/j.micpath.2017.08.035
卷: 111, 页:203-211
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Immunology ; Microbiology
研究领域[WOS]: Immunology ; Microbiology
英文摘要: We analyzed here the complete genome sequences of a highly virulent Flavobacterium columnare Pf1 strain isolated in our laboratory. The complete genome consists of a 3,171,081 bp circular DNA with 2784 predicted protein-coding genes. Among these, 286 genes were predicted as antibiotic resistance genes, including 32 RND-type efflux pump related genes which were associated with the export of amino glycosides, indicating inducible aminoglycosides resistances in F. columnare. On the other hand, 328 genes were predicted as pathogenicity related genes which could be classified as virulence factors, gliding motility proteins, adhesins, and many putative secreted proteases. These genes were probably involved in the colonization, invasion and destruction of fish tissues during the infection of E columnare. Apparently, our obtained complete genome sequences provide the basis for the explanation of the interactions between the F. columnare and the infected fish. The predicted antibiotic resistance and pathogenicity related genes will shed a new light on the development of more efficient preventional strategies against the infection of E columnare, which is a major worldwide fish pathogen. (C) 2017 Elsevier Ltd. All rights reserved.
关键词[WOS]: DEPENDENT CLP PROTEASE ; AC LYASE ACTIVITY ; ESCHERICHIA-COLI ; ACINETOBACTER-BAUMANNII ; LISTERIA-MONOCYTOGENES ; FLEXIBACTER-COLUMNARIS ; KYOTO ENCYCLOPEDIA ; CHANNEL CATFISH ; PURIFICATION ; MEMBRANE
语种: 英语
项目资助者: National Natural Science Fund(31572657 ; Administration of Ocean and Fisheries of Guangdong Province(A201512C003 ; Special fund for Science and technology from Hubei Province(2015BBA228) ; Wuhan Science and Technology Bureau(2016020101010089) ; Department of Education of Guangdong Province(KA170500G) ; Chinese Academy of Sciences (CAS)(XDA08010207) ; 31372563 ; 2015-115) ; 31602190)
WOS记录号: WOS:000412960400029
ISSN号: 0882-4010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/35724
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China
2.Zhongkai Univ Agr & Engn, Coll Anim Sci & Technol, Guangzhou Key Lab Aquat Anim Dis & Waterfowl Bree, Guangdong Prov Key Lab Waterfowl Hlth Breeding, Guangzhou 510225, Guangdong, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
4.Lake Super State Univ, Sch Biol Sci, Sault Ste Marie, MI 49783 USA
5.Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266071, Peoples R China
6.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, Guangzhou 510640, Guangdong, Peoples R China
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