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Coexposure to environmental concentrations of cis-bifenthrin and graphene oxide: Adverse effects on the nervous system during metamorphic development of Xenopus laevis
Li, Meng1; Zhu, Jiaping1; Fang, Hua1; Wang, Mengcen1; Wang, Qiangwei1; Zhou, Bingsheng2
2020-01-05
Source PublicationJOURNAL OF HAZARDOUS MATERIALS
ISSN0304-3894
Volume381Issue:1Pages:13
Abstract

Despite the great concerns associated with the combined biological effects of nanoparticles and insecticides, the current understanding of the corresponding ecological risks remains limited. Xenopus laevis (X. laevis) tadpoles were exposed to various concentrations of typical pyrethroid (cis-bifenthrin; cis-BF), either alone or in combination with graphene oxide (GO), for 21 days. The presence of GO resulted in increased bioconcentration of cis-BF and a higher 1S-enantiomer fraction. Exposure to cis-BF and GO caused further reduction in pre-metamorphic developmental rates and activated dopaminergic, noradrenergic, and serotonergic neurotransmitter systems. Reduced tadpole activity and levels of genomic DNA methylation at cytosine nucleotides (5hmC) were observed in the coexposure groups. These results indicate that GO enhance the bioconcentration of cis-BF and promote the conversion of its 1R-enantiomer to the 1S form, which lead to disruption of neurotransmitter systems as well as interference in metamorphic development.

KeywordNeurotransmitter Xenopus laevis cis-Bifenthrin Graphene oxide Coexposure
DOI10.1016/j.jhazmat.2019.120995
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS SubjectEngineering, Environmental ; Environmental Sciences
WOS IDWOS:000504778400052
WOS KeywordTITANIUM-DIOXIDE NANOPARTICLES ; THYROID ENDOCRINE DISRUPTION ; PYRETHROID INSECTICIDES ; MOLECULAR-MECHANISMS ; PHASE-CHANGE ; NEUROTOXICITY ; TOXICITY ; BIOCONCENTRATION ; EXPRESSION ; EXPOSURE
PublisherELSEVIER
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/35535
Collection水环境工程研究中心_期刊论文
Corresponding AuthorWang, Qiangwei
Affiliation1.Zhejiang Univ, Inst Pesticide & Environm Toxicol, Minist Agr, Key Lab Mol Biol Crop Pathogens & Insects, Hangzhou 310058, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Li, Meng,Zhu, Jiaping,Fang, Hua,et al. Coexposure to environmental concentrations of cis-bifenthrin and graphene oxide: Adverse effects on the nervous system during metamorphic development of Xenopus laevis[J]. JOURNAL OF HAZARDOUS MATERIALS,2020,381(1):13.
APA Li, Meng,Zhu, Jiaping,Fang, Hua,Wang, Mengcen,Wang, Qiangwei,&Zhou, Bingsheng.(2020).Coexposure to environmental concentrations of cis-bifenthrin and graphene oxide: Adverse effects on the nervous system during metamorphic development of Xenopus laevis.JOURNAL OF HAZARDOUS MATERIALS,381(1),13.
MLA Li, Meng,et al."Coexposure to environmental concentrations of cis-bifenthrin and graphene oxide: Adverse effects on the nervous system during metamorphic development of Xenopus laevis".JOURNAL OF HAZARDOUS MATERIALS 381.1(2020):13.
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