Molecular Mechanisms of Anticancer Activities of Puerarin | |
Ahmad, Bashir1; Khan, Suliman2,3; Liu, Yang2,3; Xue, Mengzhou2,3; Nabi, Ghulam4; Kumar, Sunjeet5; Alshwmi, Mohammed6; Qarluq, Abdul Wakeel7 | |
2020 | |
Source Publication | CANCER MANAGEMENT AND RESEARCH
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ISSN | 1179-1322 |
Volume | 12Issue:1Pages:79-90 |
Abstract | Medicinal plants are a vital source of natural products (NPs) that can cure cancer through modulation of different pathways, including oxidative stress, extrinsic and intrinsic apoptosis, cell cycle, inflammation, NF-kB, PI3K/AKT/mTOR, AMPK (JNK), MEK/ERK (Raf)-MEK-ERK and autophagy. Puerarin (Pue), an important NP belonging to the isoflavone glycoside group, is derived from Pueraria lobata (Willd.) Ohwi, Pueraria thomsonii Benth, and Pueraria tuberosa (Willd.). This NP was approved by the Chinese Ministry of Health for the treatment of different diseases in 1993, but it was also later reported to exhibit anticancer activity. Pue causes cancer cells death through modulation of different mechanisms including oxidative stress, intrinsic and extrinsic, Survivin and XIAP, PI3K/AKT/mTOR, Ras-Raf-MEK-ERK, JNK, cell cycle, AMPK, NF-kB, inflammation and autophagy pathways. Therefore, this review compiles for the first time the studies about the anticancer mechanism of Pue and provides comprehensive information about the anticancer effects of Pue. This review may serve as a basis for future research and clinical treatment. |
Keyword | medicinal plants natural products Puerarin Pueraria lobata Pueraria thomsonii Pueraria tuberosa |
DOI | 10.2147/CMAR.S233567 |
Indexed By | SCI |
Language | 英语 |
WOS Research Area | Oncology |
WOS Subject | Oncology |
WOS ID | WOS:000506015500001 |
WOS Keyword | NF-KAPPA-B ; ACTIVATED PROTEIN-KINASE ; ELEMENT TRANSCRIPTIONAL ACTIVITY ; CANCER CELL-PROLIFERATION ; G2/M PHASE ARREST ; NATURAL-PRODUCTS ; MULTIDRUG-RESISTANCE ; SIGNALING PATHWAYS ; UP-REGULATION ; INTRINSIC APOPTOSIS |
Publisher | DOVE MEDICAL PRESS LTD |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ihb.ac.cn/handle/342005/35526 |
Collection | 其他_期刊论文 |
Corresponding Author | Xue, Mengzhou; Nabi, Ghulam |
Affiliation | 1.Dalian Med Univ, Coll Basic Med Sci, Dept Pathol & Pathophysiol, Dalian 116044, Liaoning, Peoples R China 2.Zhengzhou Univ, Dept Cerebrovasc Dis, Affiliated Hosp 2, Zhengzhou, Peoples R China 3.Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R China 4.Hebei Normal Univ, Coll Life Sci, Key Lab Anim Physiol Biochem & Mol Biol Hebei Pro, Shijiazhuang 050024, Hebei, Peoples R China 5.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 6.Dalian Med Univ, Affiliated Hosp 1, Dept Clin Lab, Dalian 116044, Liaoning, Peoples R China 7.Dalian Med Univ, Dept Biochem & Mol Biol, Dalian 116044, Liaoning, Peoples R China |
Recommended Citation GB/T 7714 | Ahmad, Bashir,Khan, Suliman,Liu, Yang,et al. Molecular Mechanisms of Anticancer Activities of Puerarin[J]. CANCER MANAGEMENT AND RESEARCH,2020,12(1):79-90. |
APA | Ahmad, Bashir.,Khan, Suliman.,Liu, Yang.,Xue, Mengzhou.,Nabi, Ghulam.,...&Qarluq, Abdul Wakeel.(2020).Molecular Mechanisms of Anticancer Activities of Puerarin.CANCER MANAGEMENT AND RESEARCH,12(1),79-90. |
MLA | Ahmad, Bashir,et al."Molecular Mechanisms of Anticancer Activities of Puerarin".CANCER MANAGEMENT AND RESEARCH 12.1(2020):79-90. |
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