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Molecular Mechanisms of Anticancer Activities of Puerarin
Ahmad, Bashir1; Khan, Suliman2,3; Liu, Yang2,3; Xue, Mengzhou2,3; Nabi, Ghulam4; Kumar, Sunjeet5; Alshwmi, Mohammed6; Qarluq, Abdul Wakeel7
2020
Source PublicationCANCER MANAGEMENT AND RESEARCH
ISSN1179-1322
Volume12Issue:1Pages:79-90
Abstract

Medicinal plants are a vital source of natural products (NPs) that can cure cancer through modulation of different pathways, including oxidative stress, extrinsic and intrinsic apoptosis, cell cycle, inflammation, NF-kB, PI3K/AKT/mTOR, AMPK (JNK), MEK/ERK (Raf)-MEK-ERK and autophagy. Puerarin (Pue), an important NP belonging to the isoflavone glycoside group, is derived from Pueraria lobata (Willd.) Ohwi, Pueraria thomsonii Benth, and Pueraria tuberosa (Willd.). This NP was approved by the Chinese Ministry of Health for the treatment of different diseases in 1993, but it was also later reported to exhibit anticancer activity. Pue causes cancer cells death through modulation of different mechanisms including oxidative stress, intrinsic and extrinsic, Survivin and XIAP, PI3K/AKT/mTOR, Ras-Raf-MEK-ERK, JNK, cell cycle, AMPK, NF-kB, inflammation and autophagy pathways. Therefore, this review compiles for the first time the studies about the anticancer mechanism of Pue and provides comprehensive information about the anticancer effects of Pue. This review may serve as a basis for future research and clinical treatment.

Keywordmedicinal plants natural products Puerarin Pueraria lobata Pueraria thomsonii Pueraria tuberosa
DOI10.2147/CMAR.S233567
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000506015500001
WOS KeywordNF-KAPPA-B ; ACTIVATED PROTEIN-KINASE ; ELEMENT TRANSCRIPTIONAL ACTIVITY ; CANCER CELL-PROLIFERATION ; G2/M PHASE ARREST ; NATURAL-PRODUCTS ; MULTIDRUG-RESISTANCE ; SIGNALING PATHWAYS ; UP-REGULATION ; INTRINSIC APOPTOSIS
PublisherDOVE MEDICAL PRESS LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/35526
Collection其他_期刊论文
Corresponding AuthorXue, Mengzhou; Nabi, Ghulam
Affiliation1.Dalian Med Univ, Coll Basic Med Sci, Dept Pathol & Pathophysiol, Dalian 116044, Liaoning, Peoples R China
2.Zhengzhou Univ, Dept Cerebrovasc Dis, Affiliated Hosp 2, Zhengzhou, Peoples R China
3.Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R China
4.Hebei Normal Univ, Coll Life Sci, Key Lab Anim Physiol Biochem & Mol Biol Hebei Pro, Shijiazhuang 050024, Hebei, Peoples R China
5.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
6.Dalian Med Univ, Affiliated Hosp 1, Dept Clin Lab, Dalian 116044, Liaoning, Peoples R China
7.Dalian Med Univ, Dept Biochem & Mol Biol, Dalian 116044, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Ahmad, Bashir,Khan, Suliman,Liu, Yang,et al. Molecular Mechanisms of Anticancer Activities of Puerarin[J]. CANCER MANAGEMENT AND RESEARCH,2020,12(1):79-90.
APA Ahmad, Bashir.,Khan, Suliman.,Liu, Yang.,Xue, Mengzhou.,Nabi, Ghulam.,...&Qarluq, Abdul Wakeel.(2020).Molecular Mechanisms of Anticancer Activities of Puerarin.CANCER MANAGEMENT AND RESEARCH,12(1),79-90.
MLA Ahmad, Bashir,et al."Molecular Mechanisms of Anticancer Activities of Puerarin".CANCER MANAGEMENT AND RESEARCH 12.1(2020):79-90.
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