IHB OpenIR  > 水环境工程研究中心  > 期刊论文
Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling
Zhu, Junji1,2; Liu, Xing1,3,4; Cai, Xiaolian1,2; Ouyang, Gang1,3,4; Fan, Sijia1,2; Wang, Jing1,3,4; Xiao, Wuhan1,2,3,4,5
Corresponding AuthorXiao, Wuhan(w-xiao@ihb.ac.cn)
2020
Source PublicationFASEB JOURNAL
ISSN0892-6638
Volume34Issue:1Pages:988-1000
AbstractArginine methylation is a post-translational modification in histone and nonhistone proteins that can affect numerous cellular activities. Protein arginine methyltransferase 7 (Prmt7), a type III arginine methyltransferase, catalyzes the formation of stable monomethylarginines of histones. The role of PRMT7 in virus-induced innate immunity signaling, however, remains largely unknown. We demonstrate that zebrafish prmt7 could be inhibited by spring viremia of carp virus (SVCV) and grass carp reovirus (GCRV) infection. The overexpression of prmt7 suppresses cellular antiviral responses that are partially dependent on the arginine methyltransferase activity of prmt7. Consistently, prmt7-null zebrafish were more resistant to SVCV or GCRV infection, exhibiting enhanced expression of key antiviral genes and fewer necrotic cells in the liver and kidney upon viral infection. Furthermore, we established a zebrafish model to investigate grass carp hemorrhagic disease. Our findings suggest that by suppressing the RIG-I-like receptors signaling, zebrafish prmt7 negatively regulates antiviral responses, indicating the vital role of prmt7 and its arginine methyltransferase activity in innate immunity.
KeywordGCRV irf3 Prmt7 SVCV zebrafish
DOI10.1096/fj.201902219R
Funding OrganizationNational Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China (NSFC)[31830101] ; National Natural Science Foundation of China (NSFC)[31721005] ; National Natural Science Foundation of China (NSFC)[31631102] ; National Natural Science Foundation of China (NSFC)[31671315] ; National Key R & D Program of China[2018YFD0900602]
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Biology ; Cell Biology
WOS IDWOS:000507308900067
WOS KeywordPROTEIN ARGININE METHYLTRANSFERASE ; GRASS CARP REOVIRUS ; SPRING VIREMIA ; 7 PRMT7 ; RECOGNITION ; METHYLATION ; RNA ; METASTASIS ; INDUCTION ; CELLS
PublisherFEDERATION AMER SOC EXP BIOL
Funding OrganizationNational Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/35466
Collection水环境工程研究中心_期刊论文
Corresponding AuthorXiao, Wuhan
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Peoples R China
4.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China
5.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Junji,Liu, Xing,Cai, Xiaolian,et al. Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling[J]. FASEB JOURNAL,2020,34(1):988-1000.
APA Zhu, Junji.,Liu, Xing.,Cai, Xiaolian.,Ouyang, Gang.,Fan, Sijia.,...&Xiao, Wuhan.(2020).Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling.FASEB JOURNAL,34(1),988-1000.
MLA Zhu, Junji,et al."Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling".FASEB JOURNAL 34.1(2020):988-1000.
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