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Ultrahigh-cell-density heterotrophic cultivation of the unicellular green microalga Scenedesmus acuminatus and application of the cells to photoautotrophic culture enhance biomass and lipid production
Jin, Hu1; Zhang, Hu1,2; Zhou, Zhiwei3; Li, Kunpeng1; Hou, Guoli1; Xu, Quan1,2; Chuai, Wenhua4; Zhang, Chengwu3; Han, Danxiang1,5,6; Hu, Qiang1,4,5,6,7,8
2019-11-12
Source PublicationBIOTECHNOLOGY AND BIOENGINEERING
ISSN0006-3592
Issue1Pages:13
Abstract

Although production of biodiesels from microalgae is proved to be technically feasible, a commercially viable system has yet to emerge. High-cell-density fermentation of microalgae can be coupled with photoautotrophic cultivation to produce oils. In this study, by optimizing culturing conditions and employing a sophisticated substrate feed control strategy, ultrahigh-cell-density of 286 and 283.5 g/L was achieved for the unicellular alga Scenedesmus acuminatus grown in 7.5-L bench-scale and 1,000-L pilot-scale fermenters, respectively. The outdoor scale-up experiments indicated that heterotrophically grown S. acuminatus cells are more productive in terms of both biomass and lipid accumulation when they are inoculated in photobioreactors for lipid production as compared to the cells originally grown under photoautotrophic conditions. Technoeconomic analysis based on the pilot-scale data indicated that the cost of heterotrophic cultivation of microalgae for biomass production is comparable with that of the open-pond system and much lower than that of tubular PBR, if the biomass yield was higher than 200 g/L. This study demonstrated the economic viability of heterotrophic cultivation on large-scale microalgal inocula production, but ultrahigh-productivity fermentation is a prerequisite. Moreover, the advantages of the combined heterotrophic and photoautotrophic cultivation of microalgae for biofuels production were also verified in the pilot-scale.

Keywordheterotrophy high-cell-density fermentation lipid microalgae Scenedesmus acuminatus
DOI10.1002/bit.27190
Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000495819900001
WOS KeywordDILUTION-PHOTOINDUCTION CULTIVATION ; NANNOCHLOROPSIS-GADITANA INFLUENCE ; DIATOM NITZSCHIA-LAEVIS ; FED-BATCH ; HIGH-YIELD ; CHLORELLA-PROTOTHECOIDES ; EFFICIENT PRODUCTION ; MASS CULTIVATION ; PRODUCTION-RATES ; OIL PRODUCTION
PublisherWILEY
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/35397
Collection藻类生物技术和生物能源研发中心_期刊论文
Corresponding AuthorHan, Danxiang; Hu, Qiang
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Ctr Microalgal Biotechnol & Biofuels, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China
3.Jinan Univ, Res Ctr Hydrobiol, Guangzhou, Guangdong, Peoples R China
4.State Dev & Investment Corp, SDIC Biotech Investment Co Ltd, Microalgae Biotechnol Ctr, Beijing, Peoples R China
5.Chinese Acad Sci, Innovat Acad Seed Design, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan, Hubei, Peoples R China
7.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China
8.SDIC Biotech Investment Corp, Beijing Key Lab Algae Biomass, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Jin, Hu,Zhang, Hu,Zhou, Zhiwei,et al. Ultrahigh-cell-density heterotrophic cultivation of the unicellular green microalga Scenedesmus acuminatus and application of the cells to photoautotrophic culture enhance biomass and lipid production[J]. BIOTECHNOLOGY AND BIOENGINEERING,2019(1):13.
APA Jin, Hu.,Zhang, Hu.,Zhou, Zhiwei.,Li, Kunpeng.,Hou, Guoli.,...&Hu, Qiang.(2019).Ultrahigh-cell-density heterotrophic cultivation of the unicellular green microalga Scenedesmus acuminatus and application of the cells to photoautotrophic culture enhance biomass and lipid production.BIOTECHNOLOGY AND BIOENGINEERING(1),13.
MLA Jin, Hu,et al."Ultrahigh-cell-density heterotrophic cultivation of the unicellular green microalga Scenedesmus acuminatus and application of the cells to photoautotrophic culture enhance biomass and lipid production".BIOTECHNOLOGY AND BIOENGINEERING .1(2019):13.
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