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题名: Generation of ROR gamma t(+) Antigen-Specific T Regulatory 17 Cells from Foxp3(+) Precursors in Autoimmunity
作者: Kim, Byung-Seok1, 2; Lu, Huiping3, 4; Ichiyama, Kenji1; Chen, Xiang1; Zhang, Yi-Bing5; Mistry, Nipun A.6; Tanaka, Kentaro1; Lee, Young-hee1; Nurieva, Roza1; Zhang, Li7; Yang, Xuexian8; Chung, Yeonseok2; Jin, Wei3, 4; Chang, Seon Hee1; Dong, Chen3, 4
刊名: CELL REPORTS
发表日期: 2017-10-03
DOI: 10.1016/j.celrep.2017.09.021
卷: 21, 期:1, 页:195-207
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
英文摘要: Th17 cells are potent mediators in autoimmune diseases, and RORgt is required for their development. Recent studies have shown that ROR gamma t(+) Treg cells in the gut regulate intestinal inflammation by inhibiting effector T cell function. In the current study, we report that ROR gamma t(+) Treg cells were also found in lymph nodes following immunization. Not only distinct from intestinal ROR gamma t(+) Treg cells in their transcriptomes, peripheral ROR gamma t(+) Treg cells were derived from Foxp3(+) thymic Treg cells in an antigen-specific manner. Development of these ROR gamma t(+) Treg cells, coined T regulatory 17 (Tr17) cells, depended on IL-6/Stat3 signaling. Tr17 cells showed suppressive activity against antigen-specific effector T cells in vitro. In addition, Tr17 cells efficiently inhibited myelin-specific Th17-cell-mediated CNS auto-inflammation in a passive EAE model. Collectively, our study demonstrates that Tr17 cells are effector Treg cells that potentially restrict autoimmunity.
关键词[WOS]: ROR-GAMMA-T ; REMITTING MULTIPLE-SCLEROSIS ; HELPER-CELLS ; T-H-17 CELLS ; CCR6 ; DIFFERENTIATION ; TRANSCRIPTION ; EXPRESSION ; INFLAMMATION ; SUPPRESSION
语种: 英语
项目资助者: NIH(R01AR050772) ; Cancer Prevention and Research Institute of Texas(RP130078) ; Department of Defense(W81XWH-16-1-0100) ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education(2016R1A6A3A11933284) ; Arthritis Foundation of the United States(6128)
WOS记录号: WOS:000412111000017
ISSN号: 2211-1247
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/35281
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77054 USA
2.Seoul Natl Univ, Coll Pharm, Lab Immune Regulat, Seoul 08826, South Korea
3.Tsinghua Univ, Inst Immunol, Beijing 100084, Peoples R China
4.Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China
5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
6.MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77054 USA
7.Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH 45219 USA
8.Univ New Mexico, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA
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