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Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae.
Han, Jian; Liu, Kechun; Wang, Rongchun; Zhang, Yun; Zhou, Bingsheng
2019-09-01
Source PublicationAquatic Toxicology (Amsterdam)
ISSN0166-445X
Volume214Issue:1Pages:105236
Abstract

Otolith consisting largely of calcium carbonate, fibrous and proteins, is vital for maintaining body balance and/or hearing of fish. The formation of otolith involves Ca2+ transport and deposition. In the present study, we investigated the effects of Cd2+ on otoliths development by using zebrafish embryos as model. The results showed that exposure to Cd2+ inhibited the utricular and saccular otoliths growth, indicated by reduced lateral areas. Swimming speeds were reduced and a losing balance control was observed in Cd2+ exposed larvae. The genes related to Ca2+ transport (e.g. plasma membrane Ca2+ -ATPase isoform 2, pmca2; Ca2+ -ATPase isoform 2, atp2b1a) and regulation (e.g. parathyroid hormone ligand type-1, pth1; stanniocalcin isoform 1, stc1) were significantly downregulated. However, the adverse effects of Cd2+ on otoliths growth and swimming activity can be protected by supplementation of Ca2+ in exposure medium. Body burden of Cd2+ in larvae was reduced upon the supplement with Ca2+. The overall results suggest that exposure to Cd2+ can inhibit influx of Ca2+, leading to less deposition of CaCO3 for otolith growth, and finally result in impaired balance control and swimming activity in zebrafish larvae.

Indexed BySCI
Language英语
WOS Research AreaZoology ; Biochemistry & Molecular Biology ; Anatomy & Morphology ; Developmental Biology ; Genetics & Heredity ; Behavioral Sciences ; Environmental Sciences & Ecology
WOS SubjectZOOLOGY ; BIOCHEMISTRY MOLECULAR BIOLOGY ; ANATOMY MORPHOLOGY ; DEVELOPMENTAL BIOLOGY ; GENETICS HEREDITY ; BEHAVIORAL SCIENCES ; ENVIRONMENTAL SCIENCES
WOS IDWOS:ZOOR15512087933
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/35266
Collection水环境工程研究中心_期刊论文
AffiliationChinese Acad Sci, Inst Hydrobiol, Wuhan, Hubei, 430072, China
Recommended Citation
GB/T 7714
Han, Jian,Liu, Kechun,Wang, Rongchun,et al. Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae.[J]. Aquatic Toxicology (Amsterdam),2019,214(1):105236.
APA Han, Jian,Liu, Kechun,Wang, Rongchun,Zhang, Yun,&Zhou, Bingsheng.(2019).Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae..Aquatic Toxicology (Amsterdam),214(1),105236.
MLA Han, Jian,et al."Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae.".Aquatic Toxicology (Amsterdam) 214.1(2019):105236.
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