IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Infectious hematopoietic necrosis virus N protein suppresses fish IFN1 production by targeting the MITA
Wang, Zhao-Xi1,3,5; Zhou, Yu1,5; Lu, Long-Feng1; Lu, Xiao-Bing1; Ni, Bo3,6; Liu, Meng-Xi3,7; Guan, Hong-Xin3,6,7; Li, Shun1; Zhang, Yong-An1,2,4; Ouyang, Songying2,3,6,7
2020-02-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume97Issue:1Pages:523-530
Abstract

Interferon (IFN) is a vital antiviral factor in host in the early stages after the viral invasion. Meanwhile, viruses have to survive by taking advantage of the cellular machinery and complete their replication. As a result, viruses evolved several immune escape mechanisms to inhibit host IFN expression. However, the mechanisms used to escape the host's IFN system are still unclear for infectious hematopoietic necrosis virus (IHNV). In this study, we report that the N protein of IHNV inhibits IFN1 production in rainbow trout by degrading the MITA. Firstly, the upregulation of IFN1 promoter activity stimulated by poly I:C was suppressed by IHNV infection. Consistent with this result, the overexpression of the N protein of IHNV blocked the IFN1 transcription that was activated by poly I:C and MITA. Secondly, MITA was remarkably decreased by the overexpression of N protein at the protein level. Further analysis demonstrated that the N protein targeted MITA and promoted the ubiquitination of MITA. Taken together, these data suggested that the production of rainbow trout IFN1 could be suppressed by the N protein of IHNV via degrading MITA.

KeywordIHNV N protein Negative regulator MITA Interferon Rainbow trout
DOI10.1016/j.fsi.2019.12.075
Indexed BySCI
Language英语
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000513983700055
WOS KeywordINTERFERON ANTIVIRAL RESPONSE ; TROUT ONCORHYNCHUS-MYKISS ; INNATE IMMUNE-RESPONSE ; MATRIX PROTEIN ; ACTIVATION ; EXPRESSION ; RECEPTORS ; EVOLUTION ; GENE ; IHNV
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/35128
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorZhang, Yong-An; Ouyang, Songying
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266337, Peoples R China
3.Fujian Normal Univ, Coll Life Sci,Prov Univ Key Lab Cellular Stress R, Key Lab OptoElect Sci & Technol Med,Minist Educ, Key Lab Innate Immune Biol Fujian Prov,Biomed Res, Fuzhou 350117, Peoples R China
4.Huazhong Agr Univ, Coll Fisheries, State Key Lab Aquaculture Microbiol, Wuhan, Peoples R China
5.Univ Chinese Acad Sci, Beijing, Peoples R China
6.Fujian Normal Univ, Coll Life Sci, Publ Serv Platform Industrializat Dev Technol Mar, Fuzhou 350117, Peoples R China
7.Fujian Normal Univ, Fujian Key Lab Special Marine Bioresources Sustai, Fuzhou 350117, Peoples R China
Recommended Citation
GB/T 7714
Wang, Zhao-Xi,Zhou, Yu,Lu, Long-Feng,et al. Infectious hematopoietic necrosis virus N protein suppresses fish IFN1 production by targeting the MITA[J]. FISH & SHELLFISH IMMUNOLOGY,2020,97(1):523-530.
APA Wang, Zhao-Xi.,Zhou, Yu.,Lu, Long-Feng.,Lu, Xiao-Bing.,Ni, Bo.,...&Ouyang, Songying.(2020).Infectious hematopoietic necrosis virus N protein suppresses fish IFN1 production by targeting the MITA.FISH & SHELLFISH IMMUNOLOGY,97(1),523-530.
MLA Wang, Zhao-Xi,et al."Infectious hematopoietic necrosis virus N protein suppresses fish IFN1 production by targeting the MITA".FISH & SHELLFISH IMMUNOLOGY 97.1(2020):523-530.
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