IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish
Wu, Nan1; Xu, Xuan2; Wang, Biao1; Li, Xian-Mei1,3; Cheng, Ying-Yin1; Li, Ming1,4; Xia, Xiao-Qin1,3; Zhang, Yong-An1
2020-02-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume97Issue:1Pages:204-215
Abstract

Foodbome enteritis has become a limiting factor in aquaculture. Plant protein sources have already caused enteritic inflammation and inhibition in growth performance. Attempts have been made to find an effective solution to foodbome enteritis. Based on the previously suggested fish cholinergic anti-inflammatory pathway, galantamine, a typical cholinesterase inhibitor, was tested for the repression of pro-inflammatory cytokines for soybean meal induced enteritis by injection into grass carp. Both the phylogenetic analysis of cholinesterase, AchR and bioinformatic prediction, indicated galantamine's potential use as an enteritis drug. The result highlighted galantamine's potential effect for anti-enteritis in fish, especially in carps. Subsequently, a 4-week feeding trail using galantamine as an additive, in a zebrafish soybean meal induced enteritis model, demonstrated the prevention of enteritis. The results demonstrated that galantamine could prevent intestinal pathology, both histologically and molecularly, and also maintain growth performance. Reflected by gene expressional analysis, all mechanical, chemical and immune functions of the intestinal barrier could be protected by galantamine supplementation, which aided molecularly in the control of fish foodbome enteritis, through down-regulating Th17 type proinflammatory factors, meanwhile resuming the level of Treg type anti-inflammatory factors. Therefore, the current results shed light on fish intestinal acetylcholine anti-inflammation, by the dietary addition of galantamine, which could give rise to protection from foodbome enteritis.

KeywordFish foodbome enteritis Galantamine Acetylcholine anti-inflammatory pathway
DOI10.1016/j.fsi.2019.12.028
Indexed BySCI
Language英语
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000513983700023
WOS KeywordEUROPEAN SEA-BASS ; DICENTRARCHUS-LABRAX ; IMMUNE-RESPONSE ; ATLANTIC SALMON ; MEAL ; EXPRESSION ; GENE ; INVOLVEMENT ; POPULATIONS ; ACTIVATION
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/35078
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorWu, Nan
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
2.Huazhong Agr Univ, Coll Informat, Hubei Key Lab Agr Bioinformat, Wuhan, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Wu, Nan,Xu, Xuan,Wang, Biao,et al. Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish[J]. FISH & SHELLFISH IMMUNOLOGY,2020,97(1):204-215.
APA Wu, Nan.,Xu, Xuan.,Wang, Biao.,Li, Xian-Mei.,Cheng, Ying-Yin.,...&Zhang, Yong-An.(2020).Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish.FISH & SHELLFISH IMMUNOLOGY,97(1),204-215.
MLA Wu, Nan,et al."Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish".FISH & SHELLFISH IMMUNOLOGY 97.1(2020):204-215.
Files in This Item:
File Name/Size DocType Version Access License
1-s2.0-S105046481931(3631KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wu, Nan]'s Articles
[Xu, Xuan]'s Articles
[Wang, Biao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wu, Nan]'s Articles
[Xu, Xuan]'s Articles
[Wang, Biao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wu, Nan]'s Articles
[Xu, Xuan]'s Articles
[Wang, Biao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 1-s2.0-S1050464819311568-main.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.