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High-throughput transcriptome sequencing reveals the developmental toxicity mechanisms of niclosamide in zebrafish embryo
Zhu, Biran1; He, Wei2; Yang, Fan1; Chen, Lianguo3
2020-04-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume244Issue:1Pages:11
Abstract

Niclosamide (NIC) is the most widely used molluscicides for preventing the occurrence of schistosomiasis disease, and its residues can be found in various environmental samples. However, the toxicity mechanism of NIC during early developmental stage remains largely unknown. In the present study, zebrafish embryos were acutely exposed to NIC at an environmentally realistic concentration (0 and 40 mu g/L) until 120 h post-fertilization. Transcriptomic sequencing was performed to provide mechanistic insight into developmental impairment. Pathway enrichment analyses found that biological processes related to lipid metabolism were significantly affected in exposed zebrafish larvae. Consistently, biochemical measurements showed that NIC developmental exposure depleted lipid storage, elevated lipid utilization, but inhibited lipid synthesis. Furthermore, as characterized by pathway enrichment and hormonal levels, steroid hormone biosynthesis was also significantly disrupted by NIC exposure in zebrafish larvae, indicating the endocrine disrupting potential of NIC. Detoxifying phase I and II processes (e.g., metabolism, conjugation and elimination) were significantly activated by NIC exposure. Overall, our findings suggest that NIC developmental exposure at an environmentally realistic concentration disturbs the lipid metabolism, induces endocrine disruption and initiates detoxifying capacity in zebrafish larvae, which will provide preliminary clues for developmental toxicity mechanisms of NIC. (C) 2019 Elsevier Ltd. All rights reserved.

KeywordNiclosamide Zebrafish Transcriptome Endocrine disruption Lipid metabolism
DOI10.1016/j.chemosphere.2019.125468
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000515197700037
WOS KeywordDECABROMODIPHENYL ETHER BDE-209 ; LIPOPROTEIN-LIPASE ; HEPATIC LIPASE ; METABOLISM ; EXPRESSION ; SECRETION ; EXPOSURE ; BIOLOGY ; DRUG ; LEAD
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/35075
Collection水环境工程研究中心_期刊论文
Corresponding AuthorZhu, Biran; Chen, Lianguo
Affiliation1.Hubei Univ Chinese Med, Sch Basic Med Sci, Wuhan 430065, Peoples R China
2.Hubei Univ, Sch Comp Sci & Informat Engn, Wuhan 430062, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Biran,He, Wei,Yang, Fan,et al. High-throughput transcriptome sequencing reveals the developmental toxicity mechanisms of niclosamide in zebrafish embryo[J]. CHEMOSPHERE,2020,244(1):11.
APA Zhu, Biran,He, Wei,Yang, Fan,&Chen, Lianguo.(2020).High-throughput transcriptome sequencing reveals the developmental toxicity mechanisms of niclosamide in zebrafish embryo.CHEMOSPHERE,244(1),11.
MLA Zhu, Biran,et al."High-throughput transcriptome sequencing reveals the developmental toxicity mechanisms of niclosamide in zebrafish embryo".CHEMOSPHERE 244.1(2020):11.
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