IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae
Wu, Xiao Man1,4; Cao, Lu1,4; Hu, Yi Wei1,4; Chang, Ming Xian1,2,3,4
2019-11-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume94Issue:1Pages:355-372
Abstract

Streptococcus agalactiae is a major aquaculture pathogen infecting various saltwater and freshwater fish. To better understand the mechanism of the immune responses to S. agalactiae in wildtype zebrafish, the transcriptomic profiles of two organs containing mucosal-associated lymphoid tissues from S. agalactiae-infected and non-infected groups were obtained using RNA-seq techniques. In the intestines, 6735 and 12908 differently expressed genes (DEGs) were identified at 24 hpi and 48 hpi, respectively. Among 66 and 116 significantly enriched pathways, 15 and 21 pathways were involved in immune system or signal transduction at 24 hpi and 48 hpi, respectively. A number of genes involved in Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, NOD-like receptor signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, Antigen processing and presentation, NF-kappa B signaling pathway and PI3K-Akt signaling pathway were significantly downregulated. In the skins, 3113 and 4467 DEGs were identified at 24 hpi and 48 hpi, respectively. Among 24 and 56 significantly enriched pathways, 4 and 13 pathways were involved in immune system or signal transduction at 24 hpi and 48 hpi, respectively. More immune-related signaling pathways including Leukocyte transendothelial migration, Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, IL-17 signaling pathway, MAPK signaling pathway, TNF signaling pathway, Complement and coagulation cascades, Hematopoietic cell lineage and Jak-STAT signaling pathway were differently enriched for upregulated DEGs at 48 hpi, which were completely different from that in the intestines. Furthmore, comparative transcriptome analysis revealed that the downregulated 1618 genes and upregulated 1622 genes existed both at 24 hpi and 48 hpi for the intestine samples. In the skins, the downregulated 672 genes and upregulated 428 genes existed both at 24 hpi and 48 hpi. Three pathways related to immune processes were significantly enriched for downregulated DEGs both in the intestines and skins collected at 24 hpi and 48 hpi, which included Antigen processing and presentation, Intestinal immune network for IgA production and Hematopoietic cell lineage. Interaction network analysis of DEGs identified the main DEGs in the sub-network of complement and coagulation cascades both in the intestines and skins. Twenty of DEGs involved in complement and coagulation cascades were further validated by Real-time quantitative PCR. Altogether, the results obtained in this study will provide insight into the immune response of zebrafish against S. agalactiae XQ-1 infection in fatal conditions, and reveal the discrepant expression pattern of complement and coagulation cascades in the intestines and skins.

KeywordZebrafish RNA-Seq Intestine Skin Immune response Streptococcus agalactiae XQ-1
DOI10.1016/j.fsi.2019.09.040
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31873046] ; National Natural Science Foundation of China[31672687] ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China[2018CFA011] ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ04]
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000496892400039
WOS KeywordIMMUNE-RESPONSES ; PATHOGEN ENTRY ; MODEL ; DISEASE ; PROTEIN ; FISH ; COMPLEMENT ; SIGNATURES ; EFFICACY ; INVASION
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/34888
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorChang, Ming Xian
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China
2.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Hubei, Peoples R China
3.Innovat Acad Seed Design, Chinese Acad Sci, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wu, Xiao Man,Cao, Lu,Hu, Yi Wei,et al. Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae[J]. FISH & SHELLFISH IMMUNOLOGY,2019,94(1):355-372.
APA Wu, Xiao Man,Cao, Lu,Hu, Yi Wei,&Chang, Ming Xian.(2019).Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae.FISH & SHELLFISH IMMUNOLOGY,94(1),355-372.
MLA Wu, Xiao Man,et al."Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae".FISH & SHELLFISH IMMUNOLOGY 94.1(2019):355-372.
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