IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
QTL Fine Mapping for Sex Determination Region in Bighead Carp (Hypophthalmichthys nobilis) and Comparison with Silver Carp (Hypophthalmichthys molitrix)
Zhou, Ying1,2; Liu, Haiyang1; Wang, Xinhua1,3; Fu, Beide1; Yu, Xiaomu1; Tong, Jingou1
2019-11-27
Source PublicationMARINE BIOTECHNOLOGY
ISSN1436-2228
Issue1Pages:13
Abstract

Bighead carp (Hypophthalmichthys nobilis) and silver carp (Hypophthalmichthys molitrix) are genetically close aquaculture fish in the Cyprinidae, which have been confirmed to hold XX/XY sex determination. However, genomic locations of potential sex-related loci in these two fishes are still unknown. In this study, a high-resolution genetic linkage map was constructed by using 2976 SNP and 924 microsatellite markers in a F1 full-sib family of bighead carp, the length of which spanned 2022.34 cM with an average inter-marker distance of 0.52 cM. Comparative genomics revealed a high level of genomic synteny between bighead carp and zebrafish as well as grass carp. QTL fine mapping for sex trait was performed based on this linkage map of bighead carp and an unpublished linkage map of silver carp. A map distance of 3.863 cM (69.787-73.650 cM) on LG19 of bighead carp and 4.705 cM (79.096-83.801 cM) on LG21 of silver carp was significantly associated with sex phenotypes, and these two LGs are homologous between two fish species. Fourteen markers harboring in these regions were in strong linkage disequilibrium with the sex phenotype variance explained (PVE) varying from 89 to 100%. Two common markers were mapped on the QTL regions of bighead carp and silver carp, suggesting that these two carp species may have similar genetic bases for sex determination. Eleven potentially sex-related genes were identified within or near the sex QTL markers in two species. This study provided insights into elucidating mechanisms and evolution of sex determination in cyprinid fishes.

KeywordQTL Sex determination region Comparative mapping Bighead carp Silver carp Sex-related genes
DOI10.1007/s10126-019-09929-3
Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology ; Marine & Freshwater Biology
WOS SubjectBiotechnology & Applied Microbiology ; Marine & Freshwater Biology
WOS IDWOS:000501244100001
WOS KeywordTRANSMISSION RATIO DISTORTION ; QUANTITATIVE TRAIT LOCI ; LINKAGE MAP ; ARISTICHTHYS-NOBILIS ; PROVIDES INSIGHTS ; GENETIC-MAP ; FISH ; MARKERS ; GENOME ; DIFFERENTIATION
PublisherSPRINGER
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/34829
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorTong, Jingou
Affiliation1.Chinese Acad Sci, Innovat Acad Seed Design, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Henan Univ Anim Husb & Econ, Coll Anim Sci & Technol, Zhengzhou 450046, Henan, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Ying,Liu, Haiyang,Wang, Xinhua,et al. QTL Fine Mapping for Sex Determination Region in Bighead Carp (Hypophthalmichthys nobilis) and Comparison with Silver Carp (Hypophthalmichthys molitrix)[J]. MARINE BIOTECHNOLOGY,2019(1):13.
APA Zhou, Ying,Liu, Haiyang,Wang, Xinhua,Fu, Beide,Yu, Xiaomu,&Tong, Jingou.(2019).QTL Fine Mapping for Sex Determination Region in Bighead Carp (Hypophthalmichthys nobilis) and Comparison with Silver Carp (Hypophthalmichthys molitrix).MARINE BIOTECHNOLOGY(1),13.
MLA Zhou, Ying,et al."QTL Fine Mapping for Sex Determination Region in Bighead Carp (Hypophthalmichthys nobilis) and Comparison with Silver Carp (Hypophthalmichthys molitrix)".MARINE BIOTECHNOLOGY .1(2019):13.
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