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Construction of a high-density genetic linkage map and mapping of quantitative trait loci for growth-related traits in silver carp (Hypophthalmichthys molitrix)
Wang, Xinhua1,2; Liu, Haiyang2; Pang, Meixia2; Fu, Beide2; Yu, Xiaomu2; He, Shunping3; Tong, Jingou2
2019-11-25
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume9Issue:1Pages:12
Abstract

High-density genetic map and quantitative trait loci (QTL) mapping are powerful tools for identifying genomic regions that may be responsible for such polygenic trait as growth. A high-density genetic linkage map was constructed by sequencing 198 individuals in a F-1 family of silver carp (Hypophthalmichthys molitrix) in this study. This genetic map spans a length of 2,721.07 cM with 3,134 SNPs distributed on 24 linkage groups (LGs). Comparative genomic mapping presented a high level of syntenic relationship between silver carp and zebrafish. We detected one major and nineteen suggestive QTL for 4 growth-related traits (body length, body height, head length and body weight) at 6, 12 and 18 months post hatch (mph), explaining 10.2 similar to 19.5% of phenotypic variation. All six QTL for growth traits of 12 mph generally overlapped with QTL for 6 mph, while the majority of QTL for 18 mph were identified on two additional LGs, which may reveal a different genetic modulation during early and late muscle growth stages. Four potential candidate genes were identified from the QTL regions by homology searching of marker sequences against zebrafish genome. Hepcidin, a potential candidate gene identified from a QTL interval on LG16, was significantly associated with growth traits in the analyses of both phenotype-SNP association and mRNA expression between small-size and large-size groups of silver carp. These results provide a basis for elucidating the genetic mechanisms for growth and body formation in silver carp, a world aquaculture fish.

DOI10.1038/s41598-019-53469-8
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000498515100001
WOS KeywordPROVIDES INSIGHTS ; PEARL OYSTER ; BODY-WEIGHT ; GENOME ; QTL ; FISHES ; EXPRESSION ; DISTORTION ; EVOLUTION ; 2B-RAD
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/34823
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorTong, Jingou
Affiliation1.Henan Univ Anim Husb & Econ, Coll Anim Sci & Technol, Zhengzhou 450046, Henan, Peoples R China
2.Chinese Acad Sci, Innovat Acad Seed Design, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat CAS, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Wang, Xinhua,Liu, Haiyang,Pang, Meixia,et al. Construction of a high-density genetic linkage map and mapping of quantitative trait loci for growth-related traits in silver carp (Hypophthalmichthys molitrix)[J]. SCIENTIFIC REPORTS,2019,9(1):12.
APA Wang, Xinhua.,Liu, Haiyang.,Pang, Meixia.,Fu, Beide.,Yu, Xiaomu.,...&Tong, Jingou.(2019).Construction of a high-density genetic linkage map and mapping of quantitative trait loci for growth-related traits in silver carp (Hypophthalmichthys molitrix).SCIENTIFIC REPORTS,9(1),12.
MLA Wang, Xinhua,et al."Construction of a high-density genetic linkage map and mapping of quantitative trait loci for growth-related traits in silver carp (Hypophthalmichthys molitrix)".SCIENTIFIC REPORTS 9.1(2019):12.
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