IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish
Zhang, Chang1,2,3; Zhang, Qin1,2,3; Wang, Junya1,2,3; Tian, Jiayin1,2,3; Song, Yunjie1,2,3; Xie, Haixia4; Chang, Mingxian4; Nie, Pin4; Gao, Qian1,2,3; Zou, Jun1,2,3,5
2019-11-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume94Issue:1Pages:685-696
Abstract

The S100 family proteins are a group of small acidic polypeptides and have diverse functions in regulating many aspects of physiological processes. They are structurally conserved and possess two EF-hands which are central for calcium-mediated functions. In this study, 14 S100 cDNA sequences were determined in zebrafish and their genomic organizations confirmed. Re-analyzing the gene synteny of the S100 loci identified two major S100 loci in Chr16 and Chr19 which share remarkable conservation with the S100 locus in human Chri, suggesting they may have evolved from a single locus during the teleost specific whole genome duplication event. It appears that the homologues of human S100G and SlOOP have been lost in zebrafish. Expression analysis reveals that S100W, ICN1 and ICN2 are markedly expressed in embryos. Further, the transcripts of S100 genes are relatively abundant in mucosal tissues such as gills and gut. Intraperitoneal injection of poly(I:C) resulted in up-regulation of most S100 genes in the gut and spleen, with highest induction of S100V2 and S100Z detected. In fish challenged with spring viremia of carp virus (SVCV), expression of most S100 family genes was increased in the spleen between day 1 and 7 post infection, with consistent induction seen for the S100A1, S100A10b, S100B, S100ICN1, S100T, S100U, S100V1 and S100Z. Interestingly, intraperitoneal injection of Edwardsiella tardy down-regulated S100 expression in the gut but resulted in induction in the spleen. The results demonstrate that the S100 family genes are differentially modulated by bacterial and viral pathogens in zebrafish.

KeywordS100 family Gene expression Bacterial and viral infection Zebrafish
DOI10.1016/j.fsi.2019.09.051
Indexed BySCI
Language英语
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000496892400072
WOS KeywordCALCIUM-BINDING PROTEINS ; EPIDERMAL DIFFERENTIATION ; SKIN
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/34801
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorGao, Qian; Zou, Jun
Affiliation1.Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai 201306, Peoples R China
2.Shanghai Ocean Univ, Minist Sci & Technol, Int Res Ctr Marine Biosci, Shanghai, Peoples R China
3.Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
5.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Chang,Zhang, Qin,Wang, Junya,et al. Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish[J]. FISH & SHELLFISH IMMUNOLOGY,2019,94(1):685-696.
APA Zhang, Chang.,Zhang, Qin.,Wang, Junya.,Tian, Jiayin.,Song, Yunjie.,...&Zou, Jun.(2019).Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish.FISH & SHELLFISH IMMUNOLOGY,94(1),685-696.
MLA Zhang, Chang,et al."Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish".FISH & SHELLFISH IMMUNOLOGY 94.1(2019):685-696.
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