Cdk3, a conjugation-specific cyclin-dependent kinase, is essential for the initiation of meiosis in Tetrahymena thermophila | |
Yan, Guan-xiong1,2; Zhang, Jing1,2; Shodhan, Anura3; Tian, Miao1,3,4; Miao, Wei1 | |
2016 | |
Source Publication | CELL CYCLE
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ISSN | 1538-4101 |
Volume | 15Issue:18Pages:2506-2514 |
Abstract | Meiosis is an important process in sexual reproduction. Meiosis initiation has been found to be highly diverse among species. In yeast, it has been established that cyclin-dependent kinases (Cdks) and cyclins are essential components in the meiosis initiation pathway. In this study, we identified 4 Cdks in the model ciliate, Tetrahymena thermophila, and we found one of them, Cdk3, which is specifically expressed during early conjugation, to be essential for meiosis initiation. Cdk3 deletion led to arrest at the pair formation stage of conjugation. We then confirmed that Cdk3 acts upstream of double-strand break (DSB) formation. Moreover, we detected that Cdk3 is necessary for the expression of many genes involved in early meiotic events. Through proteomic quantification of phosphorylation, co-expression analysis and RNA-Seq analyses, we identified a conjugation-specific cyclin, Cyc2, which most likely partners with Cdk3 to initiate meiosis. |
Keyword | conjugation cyclin-dependent kinase meiosis initiation sexual reproduction Tetrahymena thermophila |
DOI | 10.1080/15384101.2016.1207838 |
Funding Organization | International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; OEAD (Austria) ; OEAD (Austria) ; OEAD (Austria) ; OEAD (Austria) ; OEAD (Austria) ; OEAD (Austria) ; OEAD (Austria) ; OEAD (Austria) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; 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Indexed By | SCI |
Language | 英语 |
Funding Project | International Science & Technology Cooperation Program of China[2013DFG32390] ; OEAD (Austria)[CN10/2013] ; Austrian Science Fund (FWF)[P27313-B20] ; Austrian Science Fund (FWF)[W1238-B20] |
WOS Research Area | Cell Biology |
WOS Subject | Cell Biology |
WOS ID | WOS:000384022200021 |
WOS Keyword | CELL-CYCLE ; DNA-REPLICATION ; PROTEIN-KINASE ; GENE ONTOLOGY ; FISSION YEAST ; RNA-SEQ ; PHOSPHORYLATION ; IME2 ; ACTIVATION ; GERMLINE |
Publisher | TAYLOR & FRANCIS INC |
Funding Organization | International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; OEAD (Austria) ; OEAD (Austria) ; OEAD (Austria) ; OEAD (Austria) ; OEAD (Austria) ; OEAD (Austria) ; OEAD (Austria) ; OEAD (Austria) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; 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Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ihb.ac.cn/handle/342005/34702 |
Collection | 水生生物分子与细胞生物学研究中心_期刊论文 |
Corresponding Author | Miao, Wei |
Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Univ Vienna, Dept Chromosome Biol, Ctr Mol Biol, Vienna, Austria 4.Univ Vienna, Max F Perutz Labs, Ctr Mol Biol, Vienna, Austria |
Recommended Citation GB/T 7714 | Yan, Guan-xiong,Zhang, Jing,Shodhan, Anura,et al. Cdk3, a conjugation-specific cyclin-dependent kinase, is essential for the initiation of meiosis in Tetrahymena thermophila[J]. CELL CYCLE,2016,15(18):2506-2514. |
APA | Yan, Guan-xiong,Zhang, Jing,Shodhan, Anura,Tian, Miao,&Miao, Wei.(2016).Cdk3, a conjugation-specific cyclin-dependent kinase, is essential for the initiation of meiosis in Tetrahymena thermophila.CELL CYCLE,15(18),2506-2514. |
MLA | Yan, Guan-xiong,et al."Cdk3, a conjugation-specific cyclin-dependent kinase, is essential for the initiation of meiosis in Tetrahymena thermophila".CELL CYCLE 15.18(2016):2506-2514. |
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