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Structural basis of molecular logic OR in a dual-sensor histidine kinase
Shin, Heewhan1; Ren, Zhong1; Zeng, Xiaoli1,3; Bandara, Sepalika1; Yang, Xiaojing1,2
2019-10-01
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
Volume116Issue:40Pages:19973-19982
Abstract

Signal detection and integration by sensory proteins constitute the critical molecular events as living organisms respond to changes in a complex environment. Many sensory proteins adopt a modular architecture that integrates the perception of distinct chemical or physical signals and the generation of a biological response in the same protein molecule. Currently, how signal perception and integration are achieved in such a modular, often dimeric, framework remains elusive. Here, we report a dynamic crystallography study on the tandem sensor domains of a dual-sensor histidine kinase PPHK (phosphorylation-responsive photosensitive histidine kinase) that operates a molecular logic OR, by which the output kinase activity is modulated by a phosphorylation signal and a light signal. A joint analysis of similar to 170 crystallographic datasets probing different signaling states shows remarkable dimer asymmetry as PPHK responds to the input signals and transitions from one state to the other. Supported by mutational data and structural analysis, these direct observations reveal the working mechanics of the molecular logic OR in PPHK, where the light-induced bending of a long signaling helix at the dimer interface is counteracted by the ligand-induced structural changes from a different sensor domain. We propose that the logic OR of PPHK, together with an upstream photoreceptor, implements a "long-pass" red light response distinct from those accomplished by classical phytochromes.

Keywordphotoreceptor signal integration phosphorylation molecular logic dynamic crystallography
DOI10.1073/pnas.1910855116
Funding OrganizationMichigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; 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Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; 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Indexed BySCI
Language英语
Funding ProjectMichigan Economic Development Corporation ; Michigan Technology TriCorridor[085P1000817] ; US Department of Energy, Office of Science, Office of Basic Energy Sciences[DE-AC02-06CH11357] ; NIH[R01EY024363] ; University of Illinois at Chicago ; Chicago Biomedical Consortium[CBC C-086]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000488828000038
WOS KeywordPHOTOACTIVE YELLOW PROTEIN ; SIGNAL-TRANSDUCTION ; CRYSTAL-STRUCTURE ; PHYTOCHROME ; RESOLUTION ; TIME ; BACTERIOPHYTOCHROME ; MECHANISM ; REVEALS ; MODULE
PublisherNATL ACAD SCIENCES
Funding OrganizationMichigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Economic Development Corporation ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; Michigan Technology TriCorridor ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; US Department of Energy, Office of Science, Office of Basic Energy Sciences ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; University of Illinois at Chicago ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium ; Chicago Biomedical Consortium
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/34452
Collection藻类生物学及应用研究中心_期刊论文
Corresponding AuthorYang, Xiaojing
Affiliation1.Univ Illinois, Dept Chem, Chicago, IL 60607 USA
2.Univ Illinois, Dept Ophthalmol & Vis Sci, Chicago, IL 60607 USA
3.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Shin, Heewhan,Ren, Zhong,Zeng, Xiaoli,et al. Structural basis of molecular logic OR in a dual-sensor histidine kinase[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019,116(40):19973-19982.
APA Shin, Heewhan,Ren, Zhong,Zeng, Xiaoli,Bandara, Sepalika,&Yang, Xiaojing.(2019).Structural basis of molecular logic OR in a dual-sensor histidine kinase.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,116(40),19973-19982.
MLA Shin, Heewhan,et al."Structural basis of molecular logic OR in a dual-sensor histidine kinase".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116.40(2019):19973-19982.
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