Expression and functional analysis of tumor necrosis factor receptor (TNFR)-associated factor 5 from Nile tilapia, Oreochromis niloticus | |
Xia, Hongli1,2,3; Li, Yuan4,5; Wang, Zhiwen4,5; Chen, Wenjie1,2,3,6; Cheng, Jun1,2,3; Yu, Dapeng1,2,3; Lu, Yishan1,2,3,4,5 | |
2019-10-01 | |
Source Publication | FISH & SHELLFISH IMMUNOLOGY
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ISSN | 1050-4648 |
Volume | 93Issue:1Pages:781-788 |
Abstract | Nile tilapia (Oreochromis niloticus) is a pivotal economic fish that has been plagued by Streptococcus infections. Tumor necrosis factor receptor-associated factor 5 (TRAF5) is a crucial adaptor molecule, which can trigger downstream signaling cascades involved in immune pathway. In this study, Nile tilapia TRAF5 coding sequence (named OnTRAF5) was obtained, which contained typical functional domains, such as RING, zinc finger, coiled-coil and MATH domain. Different from other TRAF molecules, OnTRAF5 had shown relatively low identify with its homolog, and it was clustered into other teleost TRAF5 proteins. qRT-PCR was used to analysis the expression level of OnTRAF5 in gill, skin, muscle, head kidney, heart, intestine, thymus, liver, spleen and brain, In healthy Nile tilapia, the expression level of OnTRAF5 in intestine, gill and spleen were significantly higher than other tissues. While under Streptococcus agalactiae infection, the expression level of OnTRAF5 was improved significantly in all detected organs. Additionally, over-expression WT OnTRAF5 activated NF-kappa B, deletion of RING or zinc finger caused the activity impaired. In conclusion, OnTRAF5 participate in anti-bacteria immune response and is crucial for the signaling transduction. |
Keyword | TRAF5 Oreochromis niloticus Streptococcus agalactiae Signal transduction |
DOI | 10.1016/j.fsi.2019.07.052 |
Funding Organization | Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; 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Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; 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Indexed By | SCI |
Language | 英语 |
Funding Project | Shenzhen Science and Technology Project[JCYJ20180306173022502] ; Shenzhen strategic emerging and future industrial development funds[20170426231005389] |
WOS Research Area | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
WOS Subject | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
WOS ID | WOS:000488998300086 |
WOS Keyword | NF-KAPPA-B ; ORANGE-SPOTTED GROUPER ; FACTOR FAMILY PROTEIN ; MOLECULAR-CLONING ; TERMINAL KINASE ; TRAF5 ; ACTIVATION ; PATHWAY ; IDENTIFICATION ; INDUCTION |
Publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
Funding Organization | Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ihb.ac.cn/handle/342005/34437 |
Collection | 淡水生态学研究中心_期刊论文 |
Corresponding Author | Lu, Yishan |
Affiliation | 1.Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518120, Peoples R China 2.Guangdong Prov Engn Res Ctr Aquat Anim Hlth Asses, Shenzhen 518120, Peoples R China 3.Shenzhen Publ Serv Platform Evaluat Marine Econ A, Shenzhen 518120, Peoples R China 4.Guangdong Ocean Univ, Coll Fishery, 1 Haida Rd, Zhanjiang 524088, Guangdong, Peoples R China 5.Guangdong Prov Key Lab Pathogen Biol & Epidemiol, Zhanjiang 524088, Peoples R China 6.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430000, Hubei, Peoples R China |
Recommended Citation GB/T 7714 | Xia, Hongli,Li, Yuan,Wang, Zhiwen,et al. Expression and functional analysis of tumor necrosis factor receptor (TNFR)-associated factor 5 from Nile tilapia, Oreochromis niloticus[J]. FISH & SHELLFISH IMMUNOLOGY,2019,93(1):781-788. |
APA | Xia, Hongli.,Li, Yuan.,Wang, Zhiwen.,Chen, Wenjie.,Cheng, Jun.,...&Lu, Yishan.(2019).Expression and functional analysis of tumor necrosis factor receptor (TNFR)-associated factor 5 from Nile tilapia, Oreochromis niloticus.FISH & SHELLFISH IMMUNOLOGY,93(1),781-788. |
MLA | Xia, Hongli,et al."Expression and functional analysis of tumor necrosis factor receptor (TNFR)-associated factor 5 from Nile tilapia, Oreochromis niloticus".FISH & SHELLFISH IMMUNOLOGY 93.1(2019):781-788. |
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