IHB OpenIR  > 淡水生态学研究中心  > 期刊论文
Expression and functional analysis of tumor necrosis factor receptor (TNFR)-associated factor 5 from Nile tilapia, Oreochromis niloticus
Xia, Hongli1,2,3; Li, Yuan4,5; Wang, Zhiwen4,5; Chen, Wenjie1,2,3,6; Cheng, Jun1,2,3; Yu, Dapeng1,2,3; Lu, Yishan1,2,3,4,5
2019-10-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume93Issue:1Pages:781-788
Abstract

Nile tilapia (Oreochromis niloticus) is a pivotal economic fish that has been plagued by Streptococcus infections. Tumor necrosis factor receptor-associated factor 5 (TRAF5) is a crucial adaptor molecule, which can trigger downstream signaling cascades involved in immune pathway. In this study, Nile tilapia TRAF5 coding sequence (named OnTRAF5) was obtained, which contained typical functional domains, such as RING, zinc finger, coiled-coil and MATH domain. Different from other TRAF molecules, OnTRAF5 had shown relatively low identify with its homolog, and it was clustered into other teleost TRAF5 proteins. qRT-PCR was used to analysis the expression level of OnTRAF5 in gill, skin, muscle, head kidney, heart, intestine, thymus, liver, spleen and brain, In healthy Nile tilapia, the expression level of OnTRAF5 in intestine, gill and spleen were significantly higher than other tissues. While under Streptococcus agalactiae infection, the expression level of OnTRAF5 was improved significantly in all detected organs. Additionally, over-expression WT OnTRAF5 activated NF-kappa B, deletion of RING or zinc finger caused the activity impaired. In conclusion, OnTRAF5 participate in anti-bacteria immune response and is crucial for the signaling transduction.

KeywordTRAF5 Oreochromis niloticus Streptococcus agalactiae Signal transduction
DOI10.1016/j.fsi.2019.07.052
Funding OrganizationShenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds
Indexed BySCI
Language英语
Funding ProjectShenzhen Science and Technology Project[JCYJ20180306173022502] ; Shenzhen strategic emerging and future industrial development funds[20170426231005389]
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000488998300086
WOS KeywordNF-KAPPA-B ; ORANGE-SPOTTED GROUPER ; FACTOR FAMILY PROTEIN ; MOLECULAR-CLONING ; TERMINAL KINASE ; TRAF5 ; ACTIVATION ; PATHWAY ; IDENTIFICATION ; INDUCTION
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Funding OrganizationShenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds ; Shenzhen strategic emerging and future industrial development funds
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/34437
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorLu, Yishan
Affiliation1.Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518120, Peoples R China
2.Guangdong Prov Engn Res Ctr Aquat Anim Hlth Asses, Shenzhen 518120, Peoples R China
3.Shenzhen Publ Serv Platform Evaluat Marine Econ A, Shenzhen 518120, Peoples R China
4.Guangdong Ocean Univ, Coll Fishery, 1 Haida Rd, Zhanjiang 524088, Guangdong, Peoples R China
5.Guangdong Prov Key Lab Pathogen Biol & Epidemiol, Zhanjiang 524088, Peoples R China
6.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430000, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Xia, Hongli,Li, Yuan,Wang, Zhiwen,et al. Expression and functional analysis of tumor necrosis factor receptor (TNFR)-associated factor 5 from Nile tilapia, Oreochromis niloticus[J]. FISH & SHELLFISH IMMUNOLOGY,2019,93(1):781-788.
APA Xia, Hongli.,Li, Yuan.,Wang, Zhiwen.,Chen, Wenjie.,Cheng, Jun.,...&Lu, Yishan.(2019).Expression and functional analysis of tumor necrosis factor receptor (TNFR)-associated factor 5 from Nile tilapia, Oreochromis niloticus.FISH & SHELLFISH IMMUNOLOGY,93(1),781-788.
MLA Xia, Hongli,et al."Expression and functional analysis of tumor necrosis factor receptor (TNFR)-associated factor 5 from Nile tilapia, Oreochromis niloticus".FISH & SHELLFISH IMMUNOLOGY 93.1(2019):781-788.
Files in This Item: Download All
File Name/Size DocType Version Access License
1-s2.0-S105046481930(3059KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xia, Hongli]'s Articles
[Li, Yuan]'s Articles
[Wang, Zhiwen]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xia, Hongli]'s Articles
[Li, Yuan]'s Articles
[Wang, Zhiwen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xia, Hongli]'s Articles
[Li, Yuan]'s Articles
[Wang, Zhiwen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 1-s2.0-S1050464819307612-main.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.