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Parental Exposure to Perfluorobutanesulfonate Impairs Offspring Development through Inheritance of Paternal Methylome
Chen, Lianguo1; Tsui, Mirabelle M. P.2; Hu, Chenyan3; Wan, Teng4; Au, Doris W. T.4; Lam, James C. W.2,5; Lam, Paul K. S.2,4; Zhou, Bingsheng1
Corresponding AuthorChen, Lianguo(lchenam@ihb.ac.cn)
2019-10-15
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume53Issue:20Pages:12018-12025
AbstractPerfluorobutanesulfonate (PFBS), an environmental pollutant of emerging concern, significantly impairs offspring development and overall health after parental exposure. However, the true inducer of offspring developmental defects among the complexity of parental influences remains unknown. In the present study, marine medaka (Oryzias melastigma) were exposed to environmentally realistic concentrations of PFBS (0, 1, 3, and 10 mu g/L) for an entire life cycle. By mixing and mating control and exposed medaka (male or female), a crossbreeding strategy was employed to produce offspring eggs from various crossbreeds, with the aim of differentiating the maternal and paternal influences. Measurements of swimming performance in larval offspring showed that larvae of exposed male parents swam hyperactively in comparison to the control larvae. Contrasting trends in PFBS transfer and maternal factor transfer (e.g., proteins and lipids) to that of swimming behavior eliminated these two factors as major inducers of offspring developmental impairment. Inheritance of the exposed paternal methylome marks in offspring may be partially responsible for abnormal swimming behavior, although different toxic mechanisms may be involved depending on the exposure concentration. Overall, these findings suggest that inheritance of epigenetic modifications implicates a long-lasting threat of PFBS to the fitness and sustainability of fish populations.
DOI10.1021/acs.est.9b03865
Funding OrganizationResearch Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong
Indexed BySCI ; SCI
Language英语
Funding ProjectResearch Grants Council Theme-Based Research Scheme[T21-602/16-R] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB14040103] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ03] ; Dean's Research Fund from The Education University of Hong Kong
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS SubjectEngineering, Environmental ; Environmental Sciences
WOS IDWOS:000491219800043
WOS KeywordEPIGENETIC TRANSGENERATIONAL ACTIONS ; MATERNAL TRANSFER ; GENOME ; PERFLUOROALKYL ; SUBSTANCES ; PERFLUOROOCTANESULFONATE ; EXPRESSION ; RESPONSES ; BEHAVIOR ; REVEALS
PublisherAMER CHEMICAL SOC
Funding OrganizationResearch Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/34415
Collection水环境工程研究中心_期刊论文
Corresponding AuthorChen, Lianguo
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China
3.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430072, Hubei, Peoples R China
4.City Univ Hong Kong, Dept Chem, Kowloon, Hong Kong, Peoples R China
5.Educ Univ Hong Kong, Dept Sci & Environm Studies, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Chen, Lianguo,Tsui, Mirabelle M. P.,Hu, Chenyan,et al. Parental Exposure to Perfluorobutanesulfonate Impairs Offspring Development through Inheritance of Paternal Methylome[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2019,53(20):12018-12025.
APA Chen, Lianguo.,Tsui, Mirabelle M. P..,Hu, Chenyan.,Wan, Teng.,Au, Doris W. T..,...&Zhou, Bingsheng.(2019).Parental Exposure to Perfluorobutanesulfonate Impairs Offspring Development through Inheritance of Paternal Methylome.ENVIRONMENTAL SCIENCE & TECHNOLOGY,53(20),12018-12025.
MLA Chen, Lianguo,et al."Parental Exposure to Perfluorobutanesulfonate Impairs Offspring Development through Inheritance of Paternal Methylome".ENVIRONMENTAL SCIENCE & TECHNOLOGY 53.20(2019):12018-12025.
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