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Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes
Wu, Xiao Man1,4; Cao, Lu1,4; Nie, Pin1,2,4; Chang, Ming Xian1,2,3,4
Corresponding AuthorChang, Ming Xian(mingxianchang@ihb.ac.cn)
2019-12-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
Volume101Pages:11
AbstractAn octamer consisting of two copies of histones H2A, H2B, H3 and H4 is the nucleosome core. It is well established that histone derived antimicrobial peptides (AMPs) have anti-microbial properties in various invertebrate and vertebrate species. Different from well-known histone H2A-derived AMPs, the antimicrobial properties of the complete histone H2A are rather limited. In the present study, we report the functional characterization of the complete histone H2A from zebrafish. The expression of zebrafish histone H2A was higher in embryos than in larvae, and inducible in response to bacterial infection. Furthermore, the expression of zebrafish histone H2A was decreased by RIP2 deficiency with and/or without bacterial infection. During Edwardsiella piscicida infection, the overexpression of zebrafish histone H2A inhibited bacterial proliferation and increased the survival rate of zebrafish larvae. The overexpression of zebrafish histone H2A demonstrated an increased transcription of many antibacterial genes and MHC related genes, which was dependent on RIP2, an adaptor protein for signal propagation of the NLRs-mediated antibacterial immune response. In line with this, zebrafish histone H2A cooperated with RIP2 to induce the transcription of many antibacterial genes and MHC related genes. All together, these results firstly demonstrate the antibacterial property of the complete histone H2A against gram-negative bacteria E. piscicida in vivo and the correlation between zebrafish histone H2A and RIP2 adaptor protein on the transcriptional regulation of antibacterial genes and MHC related genes.
KeywordZebrafish histone H2A RIP2 Bacterial infection Antibacterial genes MHC-Related genes
DOI10.1016/j.dci.2019.103455
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31873046] ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China[2018CFA011] ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ04]
WOS Research AreaFisheries ; Immunology ; Zoology
WOS SubjectFisheries ; Immunology ; Zoology
WOS IDWOS:000488141600011
WOS KeywordANTIMICROBIAL PEPTIDE ; PARASIN-I ; PROMOTER ACTIVITY ; SKIN SECRETIONS ; RAINBOW-TROUT ; PROTEIN ; APOPTOSIS ; RESPONSES ; ISOFORMS ; DYNAMICS
PublisherELSEVIER SCI LTD
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/34386
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorChang, Ming Xian
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China
2.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Hubei, Peoples R China
3.Chinese Acad Sci, Innovat Acad Seed Design, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wu, Xiao Man,Cao, Lu,Nie, Pin,et al. Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2019,101:11.
APA Wu, Xiao Man,Cao, Lu,Nie, Pin,&Chang, Ming Xian.(2019).Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,101,11.
MLA Wu, Xiao Man,et al."Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 101(2019):11.
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