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一种异育银鲫抗CyHV‑2口服重组芽孢疫苗及其制备方法
宁德刚; 韦瑶; 张磊; 费倩
Rights Holder中国科学院水生生物研究所
Date Available2017-09-05
Country中国
Subtype发明专利
Abstract本发明涉及一种异育银鲫抗鲤疱疹病毒II型(CyHV‑2)口服重组枯草芽孢杆菌芽孢疫苗及其制备方法。该疫苗是用异育银鲫颗粒饲料包被表面展示CyHV‑2免疫保护性抗原的重组枯草芽孢杆菌芽孢CyHV‑2而制得;所述芽孢是具有萌发缺陷、无抗生素抗性基因标记的芽孢。其制备方法是构建萌发缺陷、无抗生素抗性基因标记和表面展示CyHV‑2免疫保护性抗原的重组枯草芽孢杆菌芽孢,制备异育银鲫颗粒饲料包被重组芽孢的CyHV‑2口服重组芽孢疫苗,用于CyHV‑2引起的异育银鲫出血病的防治。本发明制备萌发缺陷、无抗生素抗性基因标记的表面展示CyHV‑2保护性抗原的口服重组芽孢疫苗,具有更安全和高效的特点和优势。 主权项:
Application Date2017-05-15
Language中文
Application NumberCN201710339268.1
Document Type专利
Identifierhttp://ir.ihb.ac.cn/handle/342005/34277
Collection中科院水生所知识产出(2009年前)
Recommended Citation
GB/T 7714
宁德刚,韦瑶,张磊,等. 一种异育银鲫抗CyHV‑2口服重组芽孢疫苗及其制备方法.
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