IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFN Phi 1 and IFN Phi 3 Expression through Assembly of Homo- or Heteroprotein Complexes
Feng, Hui1,2; Zhang, Qi-Min1; Zhang, Yi-Bing1; Li, Zhi1; Zhang, Jun1; Xiong, Ya-Wei1; Wu, Min1; Gui, Jian-Fang1
Corresponding AuthorZhang, Yi-Bing(ybzhang@ihb.ac.cn)
2016-09-01
Source PublicationJOURNAL OF IMMUNOLOGY
ISSN0022-1767
Volume197Issue:5Pages:1893-1904
AbstractIn mammals, IFN regulatory factor (IRF)1, IRF3, and IRF7 are three critical transcription factors that are pivotal for cooperative regulation of the type I IFN response. In this study, we explored the relative contribution of zebrafish (Danio rerio) IRF1 (DrIRF1), IRF3 (DrIRF3), and IRF7 (DrIRF7) (DrIRF1/3/7) to zebrafish IFN Phi 1 (DrIFN Phi 1) and IFN Phi 3 (DrIFN Phi 3) (DrIFN Phi 1/3) activation. Following spring viremia of carp virus infection, DrIFN Phi 1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp virus. DrIRF1/3/7 selectively bind to the IRF-binding element/IFN-stimulated regulatory element sites of DrIFN Phi 1/3 promoters, with the exception that DrIRF3 has no preference for two IRF-binding element/IFN-stimulated regulatory element motifs within the DrIFN Phi 3 promoter. Consistently, DrIRF3 alone activates DrIFN Phi 1, but not DrIFN Phi 3; DrIRF7 predominantly stimulates DrIFN Phi 3; and DrIRF1 has similar potential to DrIFN Phi 1 and DrIFN Phi 3. Strikingly, DrIRF3 facilitates the binding of DrIRF1 and DrIRF7 to both zebrafish IFN promoters, and so does DrIRF7 for the binding of DrIRF1, particularly to the DrIFN Phi 3 promoter. These binding properties correlate with differential responses of DrIFN Phi 1 and DrIFN Phi 3 to the combinatory stimulation of DrIRF1/3/7, depending on their relative amounts. Similar to the dual roles of human IRF3 in regulating IRF7-activated IFN alpha genes, DrIRF3 exerts dual effects on DrIRF1-mediated DrIFN Phi 3 gene expression: an inhibitory effect at lower concentrations and a synergistic effect at higher concentrations. These data provide evidence that fish and mammals have evolved a similar IRF-dependent regulatory mechanism fine-tuning IFN gene activation.
DOI10.4049/jimmunol.1600159
Indexed BySCI ; SCI
Language英语
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000385002300037
WOS KeywordINTERFERON ANTIVIRAL RESPONSE ; CARP CARASSIUS-AURATUS ; I INTERFERON ; MOLECULAR CHARACTERIZATION ; TRANSCRIPTION FACTORS ; DENDRITIC CELLS ; SUBCELLULAR-LOCALIZATION ; AQUACULTURE ANIMALS ; FUNCTIONAL-ANALYSIS ; ATLANTIC SALMON
PublisherAMER ASSOC IMMUNOLOGISTS
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/34144
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorZhang, Yi-Bing
Affiliation1.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA
Recommended Citation
GB/T 7714
Feng, Hui,Zhang, Qi-Min,Zhang, Yi-Bing,et al. Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFN Phi 1 and IFN Phi 3 Expression through Assembly of Homo- or Heteroprotein Complexes[J]. JOURNAL OF IMMUNOLOGY,2016,197(5):1893-1904.
APA Feng, Hui.,Zhang, Qi-Min.,Zhang, Yi-Bing.,Li, Zhi.,Zhang, Jun.,...&Gui, Jian-Fang.(2016).Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFN Phi 1 and IFN Phi 3 Expression through Assembly of Homo- or Heteroprotein Complexes.JOURNAL OF IMMUNOLOGY,197(5),1893-1904.
MLA Feng, Hui,et al."Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFN Phi 1 and IFN Phi 3 Expression through Assembly of Homo- or Heteroprotein Complexes".JOURNAL OF IMMUNOLOGY 197.5(2016):1893-1904.
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