Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia
Bi, Jianling1; Hu, Bo1; Wang, Jing1; Liu, Xing1; Zheng, Jinsong1; Wang, Ding1; Xiao, Wuhan1,2
2017-06-27
Source PublicationONCOTARGET
ISSN1949-2553
Volume8Issue:26Pages:42272-42287
AbstractAquatic mammals, such as cetaceans experience various depths, with accordingly diverse oxygenation, thus, cetaceans have developed adaptations for hypoxia, but mechanisms underlying this tolerance to low oxygen are unclear. Here we analyzed VHL and HIF-2 alpha, in the hypoxia signaling pathway. Variations in VHL are greater than HIF-2 alpha between cetaceans and terrestrial mammals, and beluga whale VHL (BW-VHL) promotes HIF-2 alpha degradation under hypoxia. BW-VHL catalyzes BW-HIF-2 alpha to form K48-linked polyubiquitin chains mainly at the lysine 429 of BW-HIF-2 alpha (K429) and induces BW-HIF-2 alpha for proteasomal degradation. W100 within BW-VHL is a key site for BW-VHL functionally and BW-VHL enhances transcriptional activity of BW-HIF-2 alpha under hypoxia. Our data therefore reveal that BW-VHL has a unique function that may contribute to hypoxic adaptation.
SubtypeArticle
KeywordBeluga Whale Cetaceans Hypoxia Hif-2 Alpha Vhl
DOI10.18632/oncotarget.15038
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationCAS Major Scientific and Technological Project(XDA08010208) ; CAS Major Scientific and Technological Project(XDA08010208) ; NSFC(31461163003 ; NSFC(31461163003 ; 91631102 ; 91631102 ; 31430080) ; 31430080) ; CAS Major Scientific and Technological Project(XDA08010208) ; CAS Major Scientific and Technological Project(XDA08010208) ; NSFC(31461163003 ; NSFC(31461163003 ; 91631102 ; 91631102 ; 31430080) ; 31430080)
Language英语
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS KeywordTUMOR-SUPPRESSOR PROTEIN ; HIGH-ALTITUDE ADAPTATION ; BAIJI LIPOTES-VEXILLIFER ; DELPHINAPTERUS-LEUCAS ; HIF-ALPHA ; MOLE-RAT ; FINLESS PORPOISE ; DIVING BEHAVIOR ; YANGTZE-RIVER ; WHITE WHALES
WOS IDWOS:000405493400045
Funding OrganizationCAS Major Scientific and Technological Project(XDA08010208) ; CAS Major Scientific and Technological Project(XDA08010208) ; NSFC(31461163003 ; NSFC(31461163003 ; 91631102 ; 91631102 ; 31430080) ; 31430080) ; CAS Major Scientific and Technological Project(XDA08010208) ; CAS Major Scientific and Technological Project(XDA08010208) ; NSFC(31461163003 ; NSFC(31461163003 ; 91631102 ; 91631102 ; 31430080) ; 31430080)
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/33714
Collection藻类生物学及应用研究中心_水生生物分子与细胞生物学研究中心
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Bi, Jianling,Hu, Bo,Wang, Jing,et al. Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia[J]. ONCOTARGET,2017,8(26):42272-42287.
APA Bi, Jianling.,Hu, Bo.,Wang, Jing.,Liu, Xing.,Zheng, Jinsong.,...&Xiao, Wuhan.(2017).Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia.ONCOTARGET,8(26),42272-42287.
MLA Bi, Jianling,et al."Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia".ONCOTARGET 8.26(2017):42272-42287.
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