IHB OpenIR  > 水环境工程研究中心  > 期刊论文
Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae
Han, Jian1; Liu, Kechun2; Wang, Rongchun2; Zhang, Yun2; Zhou, Bingsheng1
2019-09-01
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume214Issue:1Pages:9
Abstract

Otolith consisting largely of calcium carbonate, fibrous and proteins, is vital for maintaining body balance and/or hearing of fish. The formation of otolith involves Ca2+ transport and deposition. In the present study, we investigated the effects of Cd2+ on otoliths development by using zebrafish embryos as model. The results showed that exposure to Cd2+ inhibited the utricular and saccular otoliths growth, indicated by reduced lateral areas. Swimming speeds were reduced and a losing balance control was observed in Cd2+ exposed larvae. The genes related to Ca2+ transport (e.g. plasma membrane Ca2+ -ATPase isoform 2, pmca2; Ca2+ -ATPase isoform 2, atp2b1a) and regulation (e.g. parathyroid hormone ligand type-1, pth1; stanniocalcin isoform 1, stc1) were significantly downregulated. However, the adverse effects of Cd2+ on otoliths growth and swimming activity can be protected by supplementation of Ca2+ in exposure medium. Body burden of Cd2+ in larvae was reduced upon the supplement with Ca2+. The overall results suggest that exposure to Cd2+ can inhibit influx of Ca2+, leading to less deposition of CaCO3 for otolith growth, and finally result in impaired balance control and swimming activity in zebrafish larvae.

KeywordCadmium Calcium Otolith development Locomotor and balance control Zebrafish embryos/larvae
DOI10.1016/j.aquatox.2019.105236
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[21806091] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ03] ; Natural Science Foundation of Shandong Province[ZR2016YL009]
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS SubjectMarine & Freshwater Biology ; Toxicology
WOS IDWOS:000486357100002
WOS KeywordEXPRESSION ; NEUROMASTS ; ROUTES ; GROWTH
PublisherELSEVIER
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/33530
Collection水环境工程研究中心_期刊论文
Corresponding AuthorHan, Jian
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Qilu Univ Technol, Shandong Acad Sci, Biol Inst, Jinan 250014, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Han, Jian,Liu, Kechun,Wang, Rongchun,et al. Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae[J]. AQUATIC TOXICOLOGY,2019,214(1):9.
APA Han, Jian,Liu, Kechun,Wang, Rongchun,Zhang, Yun,&Zhou, Bingsheng.(2019).Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae.AQUATIC TOXICOLOGY,214(1),9.
MLA Han, Jian,et al."Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae".AQUATIC TOXICOLOGY 214.1(2019):9.
Files in This Item: Download All
File Name/Size DocType Version Access License
1-s2.0-S0166445X1930(4855KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Han, Jian]'s Articles
[Liu, Kechun]'s Articles
[Wang, Rongchun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Han, Jian]'s Articles
[Liu, Kechun]'s Articles
[Wang, Rongchun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Han, Jian]'s Articles
[Liu, Kechun]'s Articles
[Wang, Rongchun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 1-s2.0-S0166445X19304333-main.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.