Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae | |
Han, Jian1![]() | |
2019-09-01 | |
Source Publication | AQUATIC TOXICOLOGY
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ISSN | 0166-445X |
Volume | 214Issue:1Pages:9 |
Abstract | Otolith consisting largely of calcium carbonate, fibrous and proteins, is vital for maintaining body balance and/or hearing of fish. The formation of otolith involves Ca2+ transport and deposition. In the present study, we investigated the effects of Cd2+ on otoliths development by using zebrafish embryos as model. The results showed that exposure to Cd2+ inhibited the utricular and saccular otoliths growth, indicated by reduced lateral areas. Swimming speeds were reduced and a losing balance control was observed in Cd2+ exposed larvae. The genes related to Ca2+ transport (e.g. plasma membrane Ca2+ -ATPase isoform 2, pmca2; Ca2+ -ATPase isoform 2, atp2b1a) and regulation (e.g. parathyroid hormone ligand type-1, pth1; stanniocalcin isoform 1, stc1) were significantly downregulated. However, the adverse effects of Cd2+ on otoliths growth and swimming activity can be protected by supplementation of Ca2+ in exposure medium. Body burden of Cd2+ in larvae was reduced upon the supplement with Ca2+. The overall results suggest that exposure to Cd2+ can inhibit influx of Ca2+, leading to less deposition of CaCO3 for otolith growth, and finally result in impaired balance control and swimming activity in zebrafish larvae. |
Keyword | Cadmium Calcium Otolith development Locomotor and balance control Zebrafish embryos/larvae |
DOI | 10.1016/j.aquatox.2019.105236 |
Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province |
Indexed By | SCI |
Language | 英语 |
Funding Project | National Natural Science Foundation of China[21806091] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ03] ; Natural Science Foundation of Shandong Province[ZR2016YL009] |
WOS Research Area | Marine & Freshwater Biology ; Toxicology |
WOS Subject | Marine & Freshwater Biology ; Toxicology |
WOS ID | WOS:000486357100002 |
WOS Keyword | EXPRESSION ; NEUROMASTS ; ROUTES ; GROWTH |
Publisher | ELSEVIER |
Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ihb.ac.cn/handle/342005/33530 |
Collection | 水环境工程研究中心_期刊论文 |
Corresponding Author | Han, Jian |
Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China 2.Qilu Univ Technol, Shandong Acad Sci, Biol Inst, Jinan 250014, Shandong, Peoples R China |
Recommended Citation GB/T 7714 | Han, Jian,Liu, Kechun,Wang, Rongchun,et al. Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae[J]. AQUATIC TOXICOLOGY,2019,214(1):9. |
APA | Han, Jian,Liu, Kechun,Wang, Rongchun,Zhang, Yun,&Zhou, Bingsheng.(2019).Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae.AQUATIC TOXICOLOGY,214(1),9. |
MLA | Han, Jian,et al."Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae".AQUATIC TOXICOLOGY 214.1(2019):9. |
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