IHB OpenIR
Impact of chronically alternating light-dark cycles on circadian clock mediated expression of cancer (glioma)-related genes in the brain
Khan, Suliman1,2,3,4; Liu, Yang4,5; Siddique, Rabeea4,5; Nabi, Ghulam1,3; Xue, Mengzhou4,5; Hou, Hongwei1,3
2019
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN1449-2288
Volume15Issue:9Pages:1816-1834
Abstract

Disruption of the circadian rhythm is a risk factor for cancer, while glioma is a leading contributor to mortality worldwide. Substantial efforts are being undertaken to decrypt underlying molecular pathways. Our understanding of the mechanisms through which disrupted circadian rhythm induces glioma development and progression is incomplete. We, therefore, examined changes in the expression of glioma-related genes in the mouse brain after chronic jetlag (CJL) exposure. A total of 22 candidate tumor suppressor (n= 14) and oncogenes (n= 8) were identified and analyzed for their interaction with clock genes. Both the control and CJL groups were investigated for the expression of candidate genes in the nucleus accumbens, hippocampus, prefrontal cortex, hypothalamus, and striatum of wild type, Bmal1(-/-) and Cry1/2 double knockout male mice. We found significant variations in the expression of candidate tumor suppressor and oncogenes in the brain tissues after CJL treatment in the wild type, Bmal1(-/-) and Cry1/2 double knockout mice. In response to CJL treatment, some of the genes were regulated in the wild type, Bmal1(-/-) and Cry1/2 similarly. However, the expression of some of the genes indicated their association with the functional clock. Overall, our result suggests a link between CJL and gliomas risk at least partially dependent on the circadian clock. However, further studies are needed to investigate the molecular mechanism associated with CJL and gliomas.

KeywordCircadian Rhythm Clock Genes Glioma Oncogenes Tumor Suppressor Genes
DOI10.7150/ijbs.35520
Funding OrganizationNational Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; 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National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; 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National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; 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Indexed BySCI
Language英语
Funding ProjectNational Science Foundation of China[31870917] ; National Science Foundation of China[81471174] ; National Science Foundation of China[81520108011] ; National Science Foundation of China[81870942] ; National Key Research and Development Program of China[2018YFC1312200] ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000481578100004
WOS KeywordSHIFT WORK ; RISK ; DATABASE ; DISRUPTION ; POLYMORPHISMS ; ASSOCIATION ; METHYLATION ; MECHANISMS ; ACCUMBENS ; GENETICS
PublisherIVYSPRING INT PUBL
Funding OrganizationNational Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; National Science Foundation of China ; 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Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/33211
Collection中科院水生所知识产出(2009年前)
Corresponding AuthorXue, Mengzhou; Hou, Hongwei
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China
2.Minist Educ, Key Lab Mol Biophys, Wuhan 430074, Hubei, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Henan, Peoples R China
5.Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Henan, Peoples R China
Recommended Citation
GB/T 7714
Khan, Suliman,Liu, Yang,Siddique, Rabeea,et al. Impact of chronically alternating light-dark cycles on circadian clock mediated expression of cancer (glioma)-related genes in the brain[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2019,15(9):1816-1834.
APA Khan, Suliman,Liu, Yang,Siddique, Rabeea,Nabi, Ghulam,Xue, Mengzhou,&Hou, Hongwei.(2019).Impact of chronically alternating light-dark cycles on circadian clock mediated expression of cancer (glioma)-related genes in the brain.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,15(9),1816-1834.
MLA Khan, Suliman,et al."Impact of chronically alternating light-dark cycles on circadian clock mediated expression of cancer (glioma)-related genes in the brain".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 15.9(2019):1816-1834.
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