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Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR
Chen, Liang1,2; Hu, Yufei1,2; He, Jun1; Chen, Jun1; Giesy, John P.3,4,5,6; Xie, Ping1
2017-01-03
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume51Issue:1Pages:596-607
Abstract

In this study, for the first time, changes in expressions of proteins and profiles of metabolites in liver of the small, freshwater fish Danio rerio (zebrafish) were investigated after long-term exposure to environmentally relevant concentrations of microcystin-LR (MC-LR). Male zebrafish were exposed via water to 1 or 10 mu g MC-LR/L for 90 days, and iTRAQ-based proteomics and H-1 NMR-based metabolomics were employed. Histopathological observations showed that MC-LR caused damage to liver, and the effects were more pronounced in fish exposed to 10 mu g MC-LR/L. Metabolomic analysis also showed alterations of hepatic function, which included changes in a number of metabolic pathways, including small molecules involved in energy, glucose, lipids, and amino acids metabolism. Concentrations of lactate were significantly greater in individuals exposed to MC-LR than in unexposed controls. This indicated a shift toward anaerobic metabolism, which was confirmed by impaired respiration in mitochondria. Proteomics revealed that MC-LR significantly influenced multiple proteins, including those involved in folding of proteins and metabolism. Endoplasmic reticulum stress contributed to disturbance of metabolism of lipids in liver of zebrafish exposed to MC-LR. Identification of proteins and metabolites in liver of zebrafish responsive to MC-LR provides insights into mechanisms of chronic toxicity of MCs.

DOI10.1021/acs.est.6b03990
Funding OrganizationExcellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; 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Indexed BySCI
Language英语
Funding ProjectExcellent Young Scientists Fund ; National Natural Science Foundation of China[31322013] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2016FBZ08] ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China[GDT20143200016] ; Canada Research Chair program ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS SubjectEngineering, Environmental ; Environmental Sciences
WOS IDWOS:000391346900066
WOS KeywordENDOPLASMIC-RETICULUM STRESS ; FISH ORYZIAS-LATIPES ; NF-KAPPA-B ; OXIDATIVE STRESS ; DANIO-RERIO ; MEDAKA FISH ; MOLECULAR-MECHANISMS ; 1ST IDENTIFICATION ; INDUCED APOPTOSIS ; AQUATIC ANIMALS
PublisherAMER CHEMICAL SOC
Funding OrganizationExcellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; 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Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; Excellent Young Scientists Fund ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong ; Distinguished Visiting Professorship in School of Biological Sciences, University of Hong Kong
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/33123
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorChen, Jun; Xie, Ping
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK S7N 5B3, Canada
4.Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada
5.Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China
6.Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210089, Jiangsu, Peoples R China
Recommended Citation
GB/T 7714
Chen, Liang,Hu, Yufei,He, Jun,et al. Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2017,51(1):596-607.
APA Chen, Liang,Hu, Yufei,He, Jun,Chen, Jun,Giesy, John P.,&Xie, Ping.(2017).Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR.ENVIRONMENTAL SCIENCE & TECHNOLOGY,51(1),596-607.
MLA Chen, Liang,et al."Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR".ENVIRONMENTAL SCIENCE & TECHNOLOGY 51.1(2017):596-607.
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