IHB OpenIR  > 水生生物多样性与资源保护研究中心  > 期刊论文
Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae
Xiong, Xiaoqin1,2; Luo, Si1,2; Wu, Benli3; Wang, Jianwei1
Corresponding AuthorWang, Jianwei(wangjw@ihb.ac.cn)
2017-02-01
Source PublicationZEBRAFISH
ISSN1545-8547
Volume14Issue:1Pages:60-68
AbstractDimethyl sulfoxide ( DMSO), a widely used carrier solvent, can be toxic to test organisms and has species-specific sensitivity. In this study, the developmental toxicity and stress protein responses of DMSO to rare minnow (Gobiocypris rarus) and zebrafish ( Danio rerio) with two tests were compared in the early life stage. In the first test, fertilized eggs were exposed to 0%, 0.0001%, 0.001%, 0.01%, 0.1%, 1.0%, 1.5%, and 2.0% v/v of DMSO until 3 days post hatching. In the second test, larvae from 0 to 8 d were exposed to 2% DMSO until 4 days. Our results showed that DMSO was toxic to rare minnow and zebrafish on multiple indexes, and the no-observed-effect concentrations of DMSO in both species were 1.0% and 0.001% for developmental toxicity analysis and stress protein analysis, respectively. Furthermore, rare minnow larvae were more sensitive than zebrafish to DMSO for spinal malformation. The sensitive period for induction of spinal malformation by DMSO was 0-7 d after hatch (dah) for rare minnow and 0-4 dah for zebrafish. Together, these results will provide support to the use of DMSO in ecotoxicological studies using rare minnow and will contribute to a better understanding of the toxicity of DMSO.
Keyworddimethyl sulfoxide developmental toxicity stress protein responses rare minnow zebrafish
DOI10.1089/zeb.2016.1287
Funding OrganizationNational High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects
Indexed BySCI ; SCI
Language英语
Funding ProjectNational High-Tech Research and Development Projects[2012AA06A302-4]
WOS Research AreaDevelopmental Biology ; Zoology
WOS SubjectDevelopmental Biology ; Zoology
WOS IDWOS:000392882200008
WOS KeywordDANIO-RERIO EMBRYOS ; GOBIOCYPRIS-RARUS ; LARVAL DEVELOPMENT ; CARRIER SOLVENTS ; OXIDATIVE STRESS ; FATHEAD MINNOW ; DMSO ; ASSAY ; NEUROTOXICITY ; EXPOSURE
PublisherMARY ANN LIEBERT, INC
Funding OrganizationNational High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/33086
Collection水生生物多样性与资源保护研究中心_期刊论文
Corresponding AuthorWang, Jianwei
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, 7 Donghu South Rd, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Anhui Acad Agr Sci, Fisheries Res Inst, Hefei, Peoples R China
Recommended Citation
GB/T 7714
Xiong, Xiaoqin,Luo, Si,Wu, Benli,et al. Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae[J]. ZEBRAFISH,2017,14(1):60-68.
APA Xiong, Xiaoqin,Luo, Si,Wu, Benli,&Wang, Jianwei.(2017).Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae.ZEBRAFISH,14(1),60-68.
MLA Xiong, Xiaoqin,et al."Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae".ZEBRAFISH 14.1(2017):60-68.
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