IHB OpenIR  > 藻类生物学及应用研究中心  > 期刊论文
Arsenic Methyltransferase is Involved in Arsenosugar Biosynthesis by Providing DMA
Xue, Xi-Mei1; Ye, Jun1; Raber, Georg2; Francesconi, Kevin A.2; Li, Gang1; Gao, Hong3; Yan, Yu1; Rensing, Christopher4; Zhu, Yong-Guan1,5
2017-02-07
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume51Issue:3Pages:1224-1230
Abstract

Arsenic is an ubiquitous toxic element in the environment, and organisms have evolved different arsenic detoxification strategies. Studies on arsenic biotransformation mechanisms have mainly focused on arsenate (As(V)) reduction, arsenite (As(III)) oxidation, and arsenic methylation; little is known, however, about the pathway for the biosynthesis of arsenosugars, which are significant arsenic transformation products. Here, the involvement of As(III) S-Adenosylmethionine methyltransferase (ArsM) in arsenosugar synthesis is demonstrated for the first time. Synechocystis sp. PCC 6803 incubated with As(III) or monomethylarsonic acid (MMA(V)) produced dimethylarsinic acid (DMA(V)) and arsenosugars, as determined by high performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC/ICPMS). Arsenosugars were also detected in the cells when they were exposed to DMA(V). A mutant strain Synechocystis AarsM was constructed by disrupting arsM in Synechocystis sp. PCC 6803. Methylation of arsenic species was not observed in the mutant strain after exposure to arsenite or MMA(V); when Synechocystis AarsM was incubated with DMA(V), arsenosugars were detected in the cells. These results suggest that ArsM is a required enzyme for the methylation of inorganic arsenicals, but not required for the synthesis of arsenosugars from DMA, and that DMA is the precursor of arsenosugar biosynthesis. The findings will stimulate more studies on the biosynthesis of complex organoarsenicals, and lead to a better understanding of the bioavailability and function of the organoarsenicals in biological systems.

DOI10.1021/acs.est.6b04952
Funding OrganizationNational Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF)
Indexed BySCI
Language英语
Funding ProjectNational Natural Science foundation of China[21507125] ; National Natural Science foundation of China[31270161] ; Natural Science Foundation of Fujian Province[2014J01141] ; Austrian Science Fund (FWF)[23761-N17]
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS SubjectEngineering, Environmental ; Environmental Sciences
WOS IDWOS:000393738700027
WOS KeywordACCUMULATION ; PLANTS ; BIOTRANSFORMATION ; TRANSFORMATION ; ARSENOBETAINE ; CYANOBACTERIA ; PCC-6803 ; ALGA
PublisherAMER CHEMICAL SOC
Funding OrganizationNational Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; National Natural Science foundation of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Fujian Province ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF) ; Austrian Science Fund (FWF)
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/33027
Collection藻类生物学及应用研究中心_期刊论文
Corresponding AuthorZhu, Yong-Guan
Affiliation1.Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China
2.Graz Univ, Inst Chem, Graz, Austria
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
4.Fujian Agr & Forestry Univ, Coll Resources & Environm, Fuzhou, Peoples R China
5.Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Urban & Reg Ecol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Xue, Xi-Mei,Ye, Jun,Raber, Georg,et al. Arsenic Methyltransferase is Involved in Arsenosugar Biosynthesis by Providing DMA[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2017,51(3):1224-1230.
APA Xue, Xi-Mei.,Ye, Jun.,Raber, Georg.,Francesconi, Kevin A..,Li, Gang.,...&Zhu, Yong-Guan.(2017).Arsenic Methyltransferase is Involved in Arsenosugar Biosynthesis by Providing DMA.ENVIRONMENTAL SCIENCE & TECHNOLOGY,51(3),1224-1230.
MLA Xue, Xi-Mei,et al."Arsenic Methyltransferase is Involved in Arsenosugar Biosynthesis by Providing DMA".ENVIRONMENTAL SCIENCE & TECHNOLOGY 51.3(2017):1224-1230.
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