IHB OpenIR
Deep Illumina sequencing reveals conserved and novel microRNAs in grass carp in response to grass carp reovirus infection
He, Libo1; Zhang, Aidi1; Chu, Pengfei1,2; Li, Yongming1; Huang, Rong1; Liao, Lanjie1; Zhu, Zuoyan1; Wang, Yaping1
2017-02-20
Source PublicationBMC GENOMICS
ISSN1471-2164
Volume18Issue:1Pages:12
Abstract

Background: The grass carp hemorrhagic disease caused by the grass carp reovirus (GCRV) is a major disease that hampers the development of grass carp aquaculture. The mechanism underlying GCRV pathogenesis and hemorrhagic symptoms is still unknown. MicroRNAs (miRNAs) are key regulators involved in various biological processes. The aim of this study was to identify conserved and novel miRNAs in grass carp in response to GCRV infection, as well as attempt to reveal the mechanism underlying GCRV pathogenesis and hemorrhagic symptoms. Results: Grass carp were infected with GCRV, and spleen samples were collected at 0 (control), 1, 3, 5, 7, and 9 days post-infection (dpi). These samples were used to construct and sequence small RNA libraries. A total of 1208 miRNAs were identified, of which 278 were known miRNAs and 930 were novel miRNAs. Thirty-six miRNAs were identified to exhibit differential expression when compared with the control, and 536 target genes were predicted for the 36 miRNAs. GO and KEGG enrichment analyses of these target genes showed that many of the significantly enriched terms were associated with immune response, blood coagulation, hemostasis, and complement and coagulation cascades, especially the GO term "blood coagulation" and pathway "complement and coagulation cascades." Ten representative target genes involved in "complement and coagulation cascades" were selected for qPCR analysis, and the results showed that the expression patterns of these target genes were significantly upregulated at 7 dpi, suggesting that the pathway "complement and coagulation cascades" was strongly activated. Conclusion: Conserved and novel miRNAs in response to GCRV infection were identified in grass carp, of which 278 were known miRNAs and 930 were novel miRNAs. Many of the target genes involved in immune response, blood coagulation, hemostasis, and complement and coagulation cascades. Strong activation of the pathway "complement and coagulation cascades" may have led to endothelial-cell and blood-cell damage and hemorrhagic symptoms. The present study provides a new insight into understanding the mechanism underlying GCRV pathogenesis and hemorrhagic symptoms.

KeywordGrass carp Grass carp reovirus microRNA Hemorrhagic symptoms Blood coagulation Complement and coagulation cascades
DOI10.1186/s12864-017-3562-4
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31130055] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDA08030203] ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology[2014FBZ04]
WOS Research AreaBiotechnology & Applied Microbiology ; Genetics & Heredity
WOS SubjectBiotechnology & Applied Microbiology ; Genetics & Heredity
WOS IDWOS:000394419000006
WOS KeywordFLOUNDER PARALICHTHYS-OLIVACEUS ; CYTOPLASMIC RNA VIRUS ; EXPRESSION PROFILES ; PROKARYOTIC EXPRESSION ; PROTEIN EXPRESSION ; VIRAL MICRORNAS ; TELEOST FISH ; GENE ; CELLS ; ANNOTATION
PublisherBIOMED CENTRAL LTD
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Strategic Priority Research Program of Chinese Academy of Sciences ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology ; Independent Project of State Key Laboratory of Freshwater Ecology and Biotechnology
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/32971
Collection中科院水生所知识产出(2009年前)
Corresponding AuthorWang, Yaping
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
He, Libo,Zhang, Aidi,Chu, Pengfei,et al. Deep Illumina sequencing reveals conserved and novel microRNAs in grass carp in response to grass carp reovirus infection[J]. BMC GENOMICS,2017,18(1):12.
APA He, Libo.,Zhang, Aidi.,Chu, Pengfei.,Li, Yongming.,Huang, Rong.,...&Wang, Yaping.(2017).Deep Illumina sequencing reveals conserved and novel microRNAs in grass carp in response to grass carp reovirus infection.BMC GENOMICS,18(1),12.
MLA He, Libo,et al."Deep Illumina sequencing reveals conserved and novel microRNAs in grass carp in response to grass carp reovirus infection".BMC GENOMICS 18.1(2017):12.
Files in This Item: Download All
File Name/Size DocType Version Access License
s12864-017-3562-4.pd(1810KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[He, Libo]'s Articles
[Zhang, Aidi]'s Articles
[Chu, Pengfei]'s Articles
Baidu academic
Similar articles in Baidu academic
[He, Libo]'s Articles
[Zhang, Aidi]'s Articles
[Chu, Pengfei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[He, Libo]'s Articles
[Zhang, Aidi]'s Articles
[Chu, Pengfei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: s12864-017-3562-4.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.