Molecular characterization and expression analysis of three subclasses of IgT in rainbow trout (Oncorhynchus mykiss) | |
Zhang, Nu1,2; Zhang, Xu-Jie1,3; Chen, Dan-Dan1; Sunyer, J. Oriol4; Zhang, Yong-An1 | |
2017-05-01 | |
Source Publication | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
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ISSN | 0145-305X |
Volume | 70Issue:1Pages:94-105 |
Abstract | As the teleost specific immunoglobulin, IgT plays important roles in systemic and mucosal immunity. In the current study, in rainbow trout, we have cloned the heavy chain (Ig tau) genes of a secretory form of IgT2 as well as the membrane and secretory forms of a third IgT subclass, termed IgT3. Conserved cysteine and tryptophan residues that are crucial for the folding of the immunoglobulin domain as well as hydrophobic and hydrophilic residues within CART motif were identified in all IgT subclasses. Through analysis of the rainbow trout genome assembly, Ig tau 3 gene was found localized upstream of Ig tau l gene, while Ig tau 2 gene situated on another scaffold. At the transcriptional level, Ig tau 1 was mainly expressed in both systemic and mucosal lymphoid tissues, while Ig tau 2 was largely expressed in systemic lymphoid organs. After LPS and poly (I:C) treatment, Ig tau 1 and Ig tau 2 genes exhibited different expression profiles. Interestingly the transcriptional level of Ig tau 3 was negligible, although its protein product could be identified in trout serum. Importantly, a previously reported monoclonal antibody directed against trout IgT1 was able to recognize IgT2 and IgT3. These data demonstrate that there exist three subclasses of IgT in rainbow trout, and that their heavy chain genes display different expression patterns during stimulation. Overall, our data reflect the diversity and complexity of immunoglobulin in trout, thus provide a better understanding of the IgT system in the immune response of teleost fish. (C) 2017 Elsevier Ltd. All rights reserved. |
Keyword | IgT Subclass Immunoglobulin Rainbow trout |
DOI | 10.1016/j.dci.2017.01.001 |
Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; U.S. Department of Agriculture ; U.S. Department of Agriculture ; U.S. Department of Agriculture ; U.S. Department of Agriculture ; U.S. Department of Agriculture ; U.S. Department of Agriculture ; U.S. Department of Agriculture ; U.S. Department of Agriculture ; 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National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; U.S. Department of Agriculture ; U.S. Department of Agriculture ; U.S. Department of Agriculture ; U.S. Department of Agriculture ; U.S. Department of Agriculture ; U.S. Department of Agriculture ; U.S. Department of Agriculture ; U.S. Department of Agriculture ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Natural Science Foundation of China ; 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Indexed By | SCI |
Language | 英语 |
Funding Project | National Natural Science Foundation of China[31172431] ; National Basic Research Program of China[2014CB138601] ; U.S. Department of Agriculture[USDA-NRI-2013-01107] ; National Science Foundation[NSF-IOS-1457282] ; National Institutes of Health[2R01GM085207-05] |
WOS Research Area | Immunology ; Zoology |
WOS Subject | Immunology ; Zoology |
WOS ID | WOS:000394635500011 |
WOS Keyword | TELEOST FISH ; HEAVY-CHAIN ; 1ST IDENTIFICATION ; GENOME DUPLICATION ; ATLANTIC SALMON ; LYMPHOID ORGANS ; IMMUNE-SYSTEM ; B-CELLS ; EVOLUTION ; INSIGHTS |
Publisher | ELSEVIER SCI LTD |
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Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ihb.ac.cn/handle/342005/32913 |
Collection | 水生生物分子与细胞生物学研究中心_期刊论文 |
Corresponding Author | Sunyer, J. Oriol; Zhang, Yong-An |
Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China 4.Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA |
Recommended Citation GB/T 7714 | Zhang, Nu,Zhang, Xu-Jie,Chen, Dan-Dan,et al. Molecular characterization and expression analysis of three subclasses of IgT in rainbow trout (Oncorhynchus mykiss)[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2017,70(1):94-105. |
APA | Zhang, Nu,Zhang, Xu-Jie,Chen, Dan-Dan,Sunyer, J. Oriol,&Zhang, Yong-An.(2017).Molecular characterization and expression analysis of three subclasses of IgT in rainbow trout (Oncorhynchus mykiss).DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,70(1),94-105. |
MLA | Zhang, Nu,et al."Molecular characterization and expression analysis of three subclasses of IgT in rainbow trout (Oncorhynchus mykiss)".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 70.1(2017):94-105. |
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