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Integrated analysis neurimmiRs of tilapia (Oreochromis niloticus) involved in immune response to Streptococcus agalactiae, a pathogen causing meningoencephalitis in teleosts
Wang, Bei1; Gan, Zhen1,2; Wang, Zhongliang1; Yu, Dapeng1; Lin, Ziwei1; Lu, Yishan1; Wu, Zaohe1; Jian, Jichang1
2017-02-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume61Issue:1Pages:44-60
Abstract

MicroRNAs (miRNAs) are a class of noncoding RNA molecules and play important roles in a wide spectrum of biological processes, including in immune response. Recent years have witnessed considerable amount of research interest in studies on miRNA-mediated modulation gene function during neuroinflammation. Here, we evaluated Streptococcus agalactiae infected tilapia (Oreochromis niloticus) brain for the expression profile of miRNAs, potential functions and their correlation with genes involved in inflammatory pathways. A total of 1981 miRNAs were identified, including in 486 miRNAs which have homologues in the currently available databases and 1945 novel miRNAs. The expression levels of 547 miRNAs were significantly altered at 6 h-48 h post-bacterial infection, and these miRNAs were therefore classified as differentially expressed tilapia miRNAs. Real-time PCR were implemented for 14 miRNAs co-expressed in five samples, and agreement was confirmed between the high-throughput sequencing and real-time PCR data. For the 486 differentially expressed miRNAs target 41,820 genes. GO and KEGG enrichment analysis revealed that some target genes of miRNAs were grouped mainly into the categories of apoptotic, signal pathway and immune response. This is the first report of comprehensive identification of teleost miRNAs being differentially regulated in brain in normal conditions relating to bacterial infection. (C) 2016 Elsevier Ltd. All rights reserved.

KeywordOreochromis niloticus MicroRNA Streptococcus agalactiae Neuroinflammation Immune response
DOI10.1016/j.fsi.2016.12.009
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31302226] ; Science & Technology Planning Project of Guangdong Province of China[2013B020307014] ; Project of Enhancing School with Innovation[201602121]
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000394200400006
WOS KeywordFLOUNDER PARALICHTHYS-OLIVACEUS ; CONSERVED MICRORNA MIR-8 ; SMALL RNA TRANSCRIPTOMES ; TEMPORAL-LOBE EPILEPSY ; GROUP-B STREPTOCOCCUS ; BLOOD-BRAIN-BARRIER ; IMMATURE RAT MODEL ; ANGIOSTRONGYLUS-CANTONENSIS ; EXPRESSION ; INFECTION
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Science & Technology Planning Project of Guangdong Province of China ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation ; Project of Enhancing School with Innovation
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/32895
Collection其他_期刊论文
Corresponding AuthorJian, Jichang
Affiliation1.Guangdong Ocean Univ, Coll Fishery, Guangdong Higher Educ Inst,Key Lab Control Dis Aq, Guangdong Prov Key Lab Pathogen Biol & Epidemiol, Zhanjiang 524025, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Wang, Bei,Gan, Zhen,Wang, Zhongliang,et al. Integrated analysis neurimmiRs of tilapia (Oreochromis niloticus) involved in immune response to Streptococcus agalactiae, a pathogen causing meningoencephalitis in teleosts[J]. FISH & SHELLFISH IMMUNOLOGY,2017,61(1):44-60.
APA Wang, Bei.,Gan, Zhen.,Wang, Zhongliang.,Yu, Dapeng.,Lin, Ziwei.,...&Jian, Jichang.(2017).Integrated analysis neurimmiRs of tilapia (Oreochromis niloticus) involved in immune response to Streptococcus agalactiae, a pathogen causing meningoencephalitis in teleosts.FISH & SHELLFISH IMMUNOLOGY,61(1),44-60.
MLA Wang, Bei,et al."Integrated analysis neurimmiRs of tilapia (Oreochromis niloticus) involved in immune response to Streptococcus agalactiae, a pathogen causing meningoencephalitis in teleosts".FISH & SHELLFISH IMMUNOLOGY 61.1(2017):44-60.
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