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Linking genomic responses of gonads with reproductive impairment in marine medaka (Oryzias melastigma) exposed chronically to the chemopreventive and antifouling agent, 3,3'-diindolylmethane (DIM)
Chen, Lianguo1; Au, Doris W. T.2; Hu, Chenyan3; Zhang, Weipeng1; Zhou, Bingsheng4; Cai, Lin; Giesy, John P.5,6,7,8; Qian, Pei-Yuan1
2017-02-01
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume183Issue:1Pages:135-143
Abstract

3,3'-Diindolylmethane (DIM) has been promoted as an effective chemopreventive and antifouling additive. However, the concurrent risks or side effects of DIM are not fully understood, especially on tissues responsive to estrogen. Therefore, this study employed marine medaka (Oryzias melastigma) as a test model to evaluate relative safety and explore mechanisms of toxic action of DIM on development and function of gonad after chronic (28 days) aqueous exposure to relatively low doses (0 mu g/L. or 8.5 mu g/L). Integration of comprehensive toxicogenomic analysis at the transcriptome and proteome levels with apical endpoints, such as production of eggs and swimming performance of larvae, elucidated the molecular linkage in gonad from bottom up along the reproductive adverse outcome pathway. A series of sequential changes at the transcript and protein levels were linked to lesser fecundity and viability of larvae exposed to DIM. Anomalous production of vitellogenin (VTG) and eggshell proteins in testis confirmed the estrogenic potency of DIM. In the ovary, although storage of VTG was greater, lesser expressions of cathepsin enzymes blocked cleavage and incorporation of VTG into oocytes as yolk, which acted together with lower eggshell proteins to inhibit maturation of primary oocyte and thus contributed to impairment of fecundity. Overall, this study demonstrated that exposure to DIM impaired reproductive fitness. Diverse molecular initiating changes in gonads were linked to apical endpoints that could be used in assessment of risks posed by DIM on gametogenesis. In combination with chemical stability and potent endocrine disruption, the results of this study can inform decisions about the use of DIM either as chemopreventive or antifouling agent. (C) 2017 Elsevier B.V. All rights reserved.

KeywordFish Gonad Toxicogenomic Adverse apical outcome Endocrine disruption
DOI10.1016/j.aquatox.2016.12.021
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; State Administration of Foreign Experts Affairs, the P.R. China ; State Administration of Foreign Experts Affairs, the P.R. China ; State Administration of Foreign Experts Affairs, the P.R. China ; State Administration of Foreign Experts Affairs, the P.R. China ; State Administration of Foreign Experts Affairs, the P.R. China ; State Administration of Foreign Experts Affairs, the P.R. China ; State Administration of Foreign Experts Affairs, the P.R. China ; State Administration of Foreign Experts Affairs, the P.R. 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Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[41576140] ; China Ocean Mineral Resource Research and Development Association[COMRRDA12SC01] ; State Administration of Foreign Experts Affairs, the P.R. China[GDT20143200016] ; Einstein Professor Program of the Chinese Academy of Sciences ; Canada Research Chair program ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS SubjectMarine & Freshwater Biology ; Toxicology
WOS IDWOS:000394071100015
WOS KeywordRAINBOW-TROUT ; RISK-ASSESSMENT ; INDOLE-3-CARBINOL ; ESTROGEN ; TRANSCRIPTOME ; TOXICITY ; 3,3'-DIINDOLYLMETHANE ; ECOTOXICOLOGY ; DEGRADATION ; DISPOSITION
PublisherELSEVIER SCIENCE BV
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; State Administration of Foreign Experts Affairs, the P.R. China ; State Administration of Foreign Experts Affairs, the P.R. China ; State Administration of Foreign Experts Affairs, the P.R. China ; State Administration of Foreign Experts Affairs, the P.R. China ; State Administration of Foreign Experts Affairs, the P.R. China ; State Administration of Foreign Experts Affairs, the P.R. China ; State Administration of Foreign Experts Affairs, the P.R. China ; State Administration of Foreign Experts Affairs, the P.R. China ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; China Ocean Mineral Resource Research and Development Association ; State Administration of Foreign Experts Affairs, the P.R. 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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/32854
Collection水环境工程研究中心_期刊论文
Corresponding AuthorQian, Pei-Yuan
Affiliation1.Hong Kong Univ Sci & Technol, Div Life Sci, Clear Water Bay, Hong Kong, Peoples R China
2.City Univ Hong Kong, Dept Biol & Chem, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China
3.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430072, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
5.Univ Saskatchewan, Dept Vet Biomed Sci, 44 Campus Dr, Saskatoon, SK S7N 5B3, Canada
6.Univ Saskatchewan, Toxicol Ctr, 44 Campus Dr, Saskatoon, SK S7N 5B3, Canada
7.Michigan State Univ, Dept Zool, E Lansing, MI 48824 USA
8.Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA
Recommended Citation
GB/T 7714
Chen, Lianguo,Au, Doris W. T.,Hu, Chenyan,et al. Linking genomic responses of gonads with reproductive impairment in marine medaka (Oryzias melastigma) exposed chronically to the chemopreventive and antifouling agent, 3,3'-diindolylmethane (DIM)[J]. AQUATIC TOXICOLOGY,2017,183(1):135-143.
APA Chen, Lianguo.,Au, Doris W. T..,Hu, Chenyan.,Zhang, Weipeng.,Zhou, Bingsheng.,...&Qian, Pei-Yuan.(2017).Linking genomic responses of gonads with reproductive impairment in marine medaka (Oryzias melastigma) exposed chronically to the chemopreventive and antifouling agent, 3,3'-diindolylmethane (DIM).AQUATIC TOXICOLOGY,183(1),135-143.
MLA Chen, Lianguo,et al."Linking genomic responses of gonads with reproductive impairment in marine medaka (Oryzias melastigma) exposed chronically to the chemopreventive and antifouling agent, 3,3'-diindolylmethane (DIM)".AQUATIC TOXICOLOGY 183.1(2017):135-143.
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