IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Gill structural integrity changes in fish deficient or excessive in dietary isoleucine: Towards the modulation of tight junction protein, inflammation, apoptosis and antioxidant defense via NF-kappa B, TOR and Nrf2 signaling pathways
Feng, Lin1,2,3; Gan, Lu1; Jiang, Wei-Dan1,2,3; Wu, Pei1,2,3; Liu, Yang1,2,3; Jiang, Jun1,2,3; Tang, Ling4; Kuang, Sheng-Yao4; Tang, Wu-Neng4; Zhang, Yong-An5; Zhou, Xiao-Qiu1,2,3
2017-04-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume63Issue:1Pages:127-138
Abstract

This study firstly aimed to test the impact of dietary isoleucine (Ile) on tight junction protein, inflammation, apoptosis, antioxidant defense and related signaling molecule gene expression in the gill of fish. Young grass carp (Ctenopharyngodon idella) (weighing 256.8 3.5 g) were fed six diets containing graded levels of Ile, namely, 3.8, 6.6, 9.3, 12.5, 15.2 and 18.5 g/kg diet for 8 weeks. The results firstly revealed that Ile deficiency down-regulated the mRNA expressions of claudin-3, claudin-b, claudin-c, occludin and zonula occludens-1 (ZO-1) and up-regulated the mRNA expression of claudin-12, which led to the intercellular structure damage of fish gill. These effects were partially ascribed to the up-regulation of pro-inflammatory cytokines [interleukin 1 beta (IL-1 beta), interleukin 8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha)] mRNA expressions that referring to up-regulated nuclear factor kappa B P65 (NF-kappa B P65) mRNA expression and down-regulated inhibitor factor kappa B alpha (I kappa B alpha) mRNA expression, and the down-regulation of antiinflammatory cytokines [interleukin 10 (IL-10) and transforming growth factor beta 1 (TGF-beta 1)] mRNA expressions that referring to the down-regulated TOR and S6K1 mRNA expression. Interestingly, no change in claudin 15 mRNA level was observed among every treatment. At the same time, the results firstly indicated that Ile deficiency also resulted in the cellular structure damage of fish gill: (1) DNA fragmentation partially due to the up-regulation of caspase-3, caspase-8 and caspase-9 mRNA expression; (2) increase in protein carbonyl (PC), malondialdehyde (MDA) and ROS contents, which may be partially attributed to the impaired antioxidant defense [indicated by decreased glutathione (GSH) level and depressed anti-superoxide anion (ASA), anti-hydroxyl radical (a-HR), copper/zinc superoxide dismutase (Cu/Zn-SOD), catalase (CAT) and glutathione peroxidase (GPx) activities] that referring to the down regulation of corresponding antioxidant enzyme mRNA expressions and the related signaling molecules Nrf2 mRNA expression. Ile excess caused similar negative effects that observed in Ile-deficient group, whereas these negative effects were reversed with appropriate Ile supplementation. In conclusion, our results indicated that Ile deficiency or excess disrupted the structural integrity of fish gill, partially due to the trigger of apoptosis, the impairment of antioxidant defense, and the regulation of tight junction protein, inflammatory cytokines, apoptosis-related, antioxidant enzymes and related signaling molecules mRNA expressions in the fish gill. (C) 2017 Elsevier Ltd. All rights reserved.

KeywordIsoleucine Grass carp (Ctenopharyngodon idella) Structural integrity Tight junction Inflammation Antioxidant defense Gill
DOI10.1016/j.fsi.2017.02.010
Funding OrganizationNational Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; 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Indexed BySCI
Language英语
Funding ProjectNational Basic Research Program of China (973 Program)[2014CB138600] ; National Department Public Benefit Research Foundation (Agriculture) of China[201003020] ; Science and Technology Support Program of Sichuan Province of China[2014NZ0003] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2012NC0007] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2013NC0045] ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2015CC0011] ; Natural Science Foundation for Young Scientists of Sichuan Province[2014JQ0007] ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture)
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000398870700012
WOS KeywordCARP CTENOPHARYNGODON-IDELLA ; MESSENGER-RNA EXPRESSION ; OXIDATIVE STRESS ; GENE-EXPRESSION ; FRESH-WATER ; ENZYME-ACTIVITIES ; CELL-DEATH ; TRANSCRIPT ABUNDANCE ; NRF2-KEAP1 PATHWAY ; AQUATIC ORGANISMS
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Funding OrganizationNational Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; 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Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/32760
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorZhou, Xiao-Qiu
Affiliation1.Sichuan Agr Univ, Anim Nutr Inst, Chengdu 611130, Peoples R China
2.Sichuan Agr Univ, Fish Nutr & Safety Prod Univ Key Lab Sichuan Prov, Chengdu 611130, Peoples R China
3.Sichuan Agr Univ, Key Lab Anim Dis Resistance Nutr, China Minist Educ, Chengdu 611130, Peoples R China
4.Sichuan Acad Anim Sci, Anim Nutr Inst, Chengdu 610066, Peoples R China
5.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Feng, Lin,Gan, Lu,Jiang, Wei-Dan,et al. Gill structural integrity changes in fish deficient or excessive in dietary isoleucine: Towards the modulation of tight junction protein, inflammation, apoptosis and antioxidant defense via NF-kappa B, TOR and Nrf2 signaling pathways[J]. FISH & SHELLFISH IMMUNOLOGY,2017,63(1):127-138.
APA Feng, Lin.,Gan, Lu.,Jiang, Wei-Dan.,Wu, Pei.,Liu, Yang.,...&Zhou, Xiao-Qiu.(2017).Gill structural integrity changes in fish deficient or excessive in dietary isoleucine: Towards the modulation of tight junction protein, inflammation, apoptosis and antioxidant defense via NF-kappa B, TOR and Nrf2 signaling pathways.FISH & SHELLFISH IMMUNOLOGY,63(1),127-138.
MLA Feng, Lin,et al."Gill structural integrity changes in fish deficient or excessive in dietary isoleucine: Towards the modulation of tight junction protein, inflammation, apoptosis and antioxidant defense via NF-kappa B, TOR and Nrf2 signaling pathways".FISH & SHELLFISH IMMUNOLOGY 63.1(2017):127-138.
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