IHB OpenIR
Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish
Dai, Xiangyan1; Shu, Yuqin2,3; Lou, Qiyong2; Tian, Qiang1; Zhai, Gang2; Song, Jia2,3; Lu, Suxiang2,3; Yu, Hong1; He, Jiangyan2; Yin, Zhan2
2017-06-01
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN1422-0067
Volume18Issue:6Pages:20
Abstract

The regularity of Piwi-interacting RNA (piRNA) biogenesis is crucial to germline development. Functioning as Piwi-interacting proteins, Tudor domain-related proteins (Tdrds) have been demonstrated to be involved in spermatogenesis and the piRNA pathway. In this study, zebrafish tdrd12 was identified, and the maternal and germ cell-specific expression patterns of zebrafish tdrd12 were observed. Utilizing TALEN (transcription activator-like effector nuclease) techniques, two independent tdrd12 mutant zebrafish lines were generated. Although no defects were found during the generation of the primordial germ cells (PGCs) in the tdrd12-null fish progenies obtained from the heterozygous tdrd12 mutant parents, all Tdrd12-deficient fish developed into infertile males. The reduced numbers and eventually loss of the germ cells by 35 days post fertilization (dpf) led to masculinization and infertility of the Tdrd12-deficient fish. Meiosis defects of the germ cells in the tdrd12 mutants during the gonad-transitioning period were observed, revealing the indispensable functions of Tdrd12 in gametogenesis. Our studies demonstrated that zebrafish Tdrd12 is essential for germ cell development and maintenance.

Keywordtdrd12 knockout germ cell differentiation maintenance zebrafish
DOI10.3390/ijms18061127
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; 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Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31530077] ; National Basic Research Program of China (973 Program)[2014CB138602]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000404581500027
WOS KeywordDOMAIN-CONTAINING PROTEINS ; TUDOR-RELATED GENE ; SEX DETERMINATION ; PIRNA BIOGENESIS ; PIWI PROTEINS ; MOLECULAR SCAFFOLD ; DIFFERENTIATION ; MICE ; EXPRESSION ; SPERMATOGENESIS
PublisherMDPI AG
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; 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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/32519
Collection中科院水生所知识产出(2009年前)
Corresponding AuthorYin, Zhan
Affiliation1.Southwest Med Univ, Dept Med Cell Biol & Genet, Coll Preclin Med, Luzhou 646000, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Dai, Xiangyan,Shu, Yuqin,Lou, Qiyong,et al. Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017,18(6):20.
APA Dai, Xiangyan.,Shu, Yuqin.,Lou, Qiyong.,Tian, Qiang.,Zhai, Gang.,...&Yin, Zhan.(2017).Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(6),20.
MLA Dai, Xiangyan,et al."Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18.6(2017):20.
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