IHB OpenIR  > 淡水生态学研究中心  > 期刊论文
Grass Carp Reovirus VP41 Targets Fish MITA To Abrogate the Interferon Response
Lu, Long-Feng1,2; Li, Shun1,3; Wang, Zhao-Xi1,2; Du, Si-Qi4; Chen, Dan-Dan1,3; Nie, Pin1,3; Zhang, Yong-An1,3
2017-07-01
Source PublicationJOURNAL OF VIROLOGY
ISSN0022-538X
Volume91Issue:14Pages:15
Abstract

Although fish possess an efficient interferon (IFN) system to defend against aquatic virus infection, grass carp reovirus (GCRV) still causes hemorrhagic disease in grass carp. To date, GCRV's strategy for evading the fish IFN response is still unknown. Here, we report that GCRV VP41 inhibits fish IFN production by suppressing the phosphorylation of mediator of IFN regulatory factor 3 (IRF3) activation (MITA). First, the activation of the IFN promoter (IFNpro) stimulated by mitochondrial antiviral signaling protein (MAVS) and MITA was decreased by the overexpression of VP41, whereas such activation induced by TANK-binding kinase 1 (TBK1) was not affected. Second, VP41 was colocalized in the cellular endoplasmic reticulum (ER) and associated with MITA. Furthermore, as a phosphorylation substrate of TBK1, VP41 significantly decreased the phosphorylation of MITA. Truncation assays indicated that the transmembrane (TM) region of VP41 was indispensable for the suppression of IFNpro activity. Finally, after infection with GCRV, VP41 blunted the transcription of host IFN and facilitated viral RNA synthesis. Taken together, our findings suggest that GCRV VP41 prevents the fish IFN response by attenuating the phosphorylation of MITA for viral evasion. IMPORTANCE MITA is thought to act as an adaptor protein to facilitate the phosphorylation of IRF3 by TBK1 upon viral infection, and it plays a critical role in innate antiviral responses. Here, we report that GCRV VP41 colocalizes with MITA at the ER and reduces MITA phosphorylation by acting as a decoy substrate of TBK1, thus inhibiting IFN production. These findings reveal GCRV's strategy for evading the host IFN response for the first time.

KeywordVP41 GCRV immune evasion MITA interferon
DOI10.1128/JVI.00390-17
Funding OrganizationNational Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
Indexed BySCI
Language英语
Funding ProjectNational Basic Research Program of China ; CAS Major Scientific and Technological Project[2014CB138601] ; CAS Major Scientific and Technological Project[XDA08010207] ; National Natural Science Foundation of China[31502200]
WOS Research AreaVirology
WOS SubjectVirology
WOS IDWOS:000405465700023
WOS KeywordHEPATITIS-C VIRUS ; ANTIVIRAL SIGNALING PROTEIN ; INNATE IMMUNE RECOGNITION ; COMPLETE GENOME SEQUENCE ; CYCLIC-DI-GMP ; RIG-I ; ADAPTER PROTEIN ; ENDOPLASMIC-RETICULUM ; REGULATORY FACTOR-3 ; ONCORHYNCHUS-MYKISS
PublisherAMER SOC MICROBIOLOGY
Funding OrganizationNational Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/32501
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorZhang, Yong-An
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Peoples R China
4.Wuhan Univ, Coll Life Sci, Wuhan, Peoples R China
Recommended Citation
GB/T 7714
Lu, Long-Feng,Li, Shun,Wang, Zhao-Xi,et al. Grass Carp Reovirus VP41 Targets Fish MITA To Abrogate the Interferon Response[J]. JOURNAL OF VIROLOGY,2017,91(14):15.
APA Lu, Long-Feng.,Li, Shun.,Wang, Zhao-Xi.,Du, Si-Qi.,Chen, Dan-Dan.,...&Zhang, Yong-An.(2017).Grass Carp Reovirus VP41 Targets Fish MITA To Abrogate the Interferon Response.JOURNAL OF VIROLOGY,91(14),15.
MLA Lu, Long-Feng,et al."Grass Carp Reovirus VP41 Targets Fish MITA To Abrogate the Interferon Response".JOURNAL OF VIROLOGY 91.14(2017):15.
Files in This Item: Download All
File Name/Size DocType Version Access License
Journal of Virology-(2241KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Lu, Long-Feng]'s Articles
[Li, Shun]'s Articles
[Wang, Zhao-Xi]'s Articles
Baidu academic
Similar articles in Baidu academic
[Lu, Long-Feng]'s Articles
[Li, Shun]'s Articles
[Wang, Zhao-Xi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lu, Long-Feng]'s Articles
[Li, Shun]'s Articles
[Wang, Zhao-Xi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Journal of Virology-2017-Lu-e00390-17.full.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.