IHB OpenIR  > 水环境工程研究中心  > 期刊论文
Perfluorobutanesulfonate Exposure Skews Sex Ratio in Fish and Transgenerationally Impairs Reproduction
Chen, Lianguo1; Lam, James C. W.2,3; Hu, Chenyan4; Tsui, Mirabelle M. P.2; Lam, Paul K. S.2; Zhou, Bingsheng1
Corresponding AuthorChen, Lianguo(lchenam@ihb.ac.cn)
2019-07-16
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume53Issue:14Pages:8389-8397
AbstractPerfluorobutanesulfonate (PFBS) is increasingly polluting aquatic environments due to worldwide manufacturing and application. However, toxicological knowledge regarding PFBS exposure remains scarce. Here, we showed that PFBS life-cycle exposure at environmentally realistic concentrations (0, 1.0, 2.9, and 9.5 mu g/L) skewed the sex ratio in fish toward male dominance, while reproductive functions of female fish were greatly impaired, as characterized by extremely small ovaries, blocked oocyte development, and decreased egg production. Endocrine disruption through the hypothalamus-pituitary-gonad axis was induced by PFBS exposure, showing antiestrogenic activity in females but estrogenic activity in males. PFBS was found to gradually accumulate in F0 adults during continuous exposure but can be rapidly eliminated when depurated in clean water. Parental exposure also transferred PFBS pollutant to F1 offspring eggs. Although no trace of PFBS was detected in F1 adults and F2 eggs, adverse effects from parental exposure persisted in F1 and F2 offspring. These transgenerational effects implicate PFBS as an ongoing threat to the fitness and sustainability of fish populations. The dramatic impairment of fish reproduction highlights the urgency of re-evaluations of the ecological and evolutionary consequences of PFBS exposure.
DOI10.1021/acs.est.9b01711
Funding OrganizationResearch Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology
Indexed BySCI ; SCI
Language英语
Funding ProjectResearch Grants Council Theme-Based Research Scheme[T21-602/16-R] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ03]
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS SubjectEngineering, Environmental ; Environmental Sciences
WOS IDWOS:000476685500049
WOS KeywordMEDAKA ORYZIAS-LATIPES ; GENE-EXPRESSION ; MARINE FISH ; PERFLUOROALKYL ; SUBSTANCES ; REVERSAL ; PERFLUOROOCTANESULFONATE ; DIFFERENTIATION ; POLLUTANTS ; RESPONSES
PublisherAMER CHEMICAL SOC
Funding OrganizationResearch Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/32145
Collection水环境工程研究中心_期刊论文
Corresponding AuthorChen, Lianguo
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China
3.Educ Univ Hong Kong, Dept Sci & Environm Studies, Hong Kong, Peoples R China
4.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Chen, Lianguo,Lam, James C. W.,Hu, Chenyan,et al. Perfluorobutanesulfonate Exposure Skews Sex Ratio in Fish and Transgenerationally Impairs Reproduction[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2019,53(14):8389-8397.
APA Chen, Lianguo,Lam, James C. W.,Hu, Chenyan,Tsui, Mirabelle M. P.,Lam, Paul K. S.,&Zhou, Bingsheng.(2019).Perfluorobutanesulfonate Exposure Skews Sex Ratio in Fish and Transgenerationally Impairs Reproduction.ENVIRONMENTAL SCIENCE & TECHNOLOGY,53(14),8389-8397.
MLA Chen, Lianguo,et al."Perfluorobutanesulfonate Exposure Skews Sex Ratio in Fish and Transgenerationally Impairs Reproduction".ENVIRONMENTAL SCIENCE & TECHNOLOGY 53.14(2019):8389-8397.
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