IHB OpenIR  > 水环境工程研究中心  > 期刊论文
Pentachlorophenol affected both reproductive and interrenal systems: In silico and in vivo evidence
Yang, Lihua1; Zha, Jinmiao2,3; Wang, Zijian4
2017
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume166Issue:1Pages:174-183
Abstract

The present study investigated the effects on reproductive and interrenal system by pentachlorophenol (PCP) using in silico and in vivo assays. Molecular docking results indicated interacting potency of PCP with steroid receptors (ER alpha, ER beta, AR, GR) but not Cytochrome P450 enzymes (CYPs). In the in vivo assay, sexually matured rare minnow (Gobiocypris rams) was exposed to environmental relevant concentrations of PCP (0, 0.5, 5, 50 mu g L-1). In male fish, 14-d exposure caused up-regulation of mRNA levels of hepatic er alpha, er beta, ar, gr, vtg and gonadal er alpha, vtg, ar, dmrt1, providing evidence for agonistic activities for steroid receptors by PCP. The up-regulated mRNA of gnrh, crf, pomc in the brain also indicated feed forward responses of the hypothalamic-pituitary-gonadal/interrenal (HPG/I) axis. However, at 28th d the feed-forward response of the HPG axis seemed eased back and the HPI axis showed negative feedback responses. Corresponding changes including increases of plasma steroid hormones, inhibition of spermatogenesis, and decreased RSI were observed in male fish upon 28-d exposure to PCP. In the females, a transition from feed-forward responses to negative feedbacks of the HPG/I axis was also indicated by the transcriptional profiles at 14th and 28th day. Corresponding changes including increased E2, T and decreased C levels, degenerated ovaries, and decreased GSI and RSI were also observed. Overall, we concluded that PCP could interfere with steroid receptors, evoke responses of HPG/I axis, and finally result in adverse effects on reproductive and interrenal system in rare minnow at environmental relevant concentrations. (C) 2016 Elsevier Ltd. All rights reserved.

KeywordPentachlorophenol Molecular docking Chinese rare minnow (Gobiocypris rarus) Reproductive system Interrenal system
DOI10.1016/j.chemosphere.2016.09.099
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[21307153] ; National Natural Science Foundation of China[21407166] ; Beijing Natural Science Foundation[8152017]
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000386186400018
WOS KeywordMINNOW GOBIOCYPRIS-RARUS ; MEDIATED GENE-EXPRESSION ; POLYBROMINATED DIPHENYL ETHERS ; ESTROGEN-RECEPTOR-ALPHA ; MEDAKA ORYZIAS-LATIPES ; 2-HYBRID YEAST ASSAY ; RAINBOW-TROUT ; GLUCOCORTICOID-RECEPTOR ; DMRT1 EXPRESSION ; HORMONE-ACTIVITY
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/31966
Collection水环境工程研究中心_期刊论文
Corresponding AuthorZha, Jinmiao
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Drinking Water Sci & Technol, POB 2871,Shuangqing Rd 18, Beijing 100085, Peoples R China
3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing Key Lab Ind Wastewater Treatment & Reuse, Beijing 100085, Peoples R China
4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Aquat Chem, POB 2871, Beijing 100085, Peoples R China
Recommended Citation
GB/T 7714
Yang, Lihua,Zha, Jinmiao,Wang, Zijian. Pentachlorophenol affected both reproductive and interrenal systems: In silico and in vivo evidence[J]. CHEMOSPHERE,2017,166(1):174-183.
APA Yang, Lihua,Zha, Jinmiao,&Wang, Zijian.(2017).Pentachlorophenol affected both reproductive and interrenal systems: In silico and in vivo evidence.CHEMOSPHERE,166(1),174-183.
MLA Yang, Lihua,et al."Pentachlorophenol affected both reproductive and interrenal systems: In silico and in vivo evidence".CHEMOSPHERE 166.1(2017):174-183.
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