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Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7
Liu, Xing1; Cai, Xiaolian1; Zhang, Dawei1; Xu, Chenxi1; Xiao, Wuhan1,2
2016-12-15
Source PublicationJOURNAL OF IMMUNOLOGY
ISSN0022-1767
Volume197Issue:12Pages:4736-4749
Abstract

Forkhead box O (FOXO)3, a member of the FOXO family of transcription factors, plays key roles in various cellular processes, including development, longevity, reproduction, and metabolism. Recently, FOXO3 has also been shown to be involved in modulating the immune response. However, how FOXO3 regulates immunity and the underlying mechanisms are still largely unknown. In this study, we show that zebrafish (Danio rerio) foxo3b, an ortholog of mammalian FOXO3, is induced by polyinosinic-polycytidylic acid stimulation and spring viremia of carp virus (SVCV) infection. We found that foxo3b interacted with irf3 and irf7 to inhibit ifr3/irf7 transcriptional activity, thus resulting in suppression of SVCV or polyinosinic-polycytidylic acid-induced IFN activation. By suppressing expression of key antiviral genes, foxo3b negatively regulated the cellular antiviral response. Furthermore, upon SVCV infection, the expression of the key antiviral genes was significantly enhanced in foxo3b-null zebrafish larvae compared with wild-type larvae. Additionally, the replication of SVCV was inhibited in foxo3b-null zebrafish larvae, leading to a higher survival rate. Our findings suggest that by suppressing irf3/irf7 activity, zebrafish foxo3b negatively regulates the antiviral response, implicating the vital role of the FOXO gene family in innate immunity.

DOI10.4049/jimmunol.1601187
Funding OrganizationChinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
Indexed BySCI
Language英语
Funding ProjectChinese Academy of Sciences Major Scientific and Technological Project[XDA08010208] ; National Natural Science Foundation of China[31461163003] ; National Natural Science Foundation of China[31671315] ; National Natural Science Foundation of China[91631102] ; National Natural Science Foundation of China[31401072]
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000389635900024
WOS KeywordFORKHEAD TRANSCRIPTION FACTOR ; DEPENDENT PROTEIN-KINASE ; OXIDATIVE STRESS ; INNATE IMMUNITY ; TELEOST FISH ; KAPPA-B ; INTERFERON ; METHYLATION ; ACTIVATION ; RECEPTORS
PublisherAMER ASSOC IMMUNOLOGISTS
Funding OrganizationChinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/31908
Collection水环境工程研究中心_期刊论文
Corresponding AuthorXiao, Wuhan
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xing,Cai, Xiaolian,Zhang, Dawei,et al. Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7[J]. JOURNAL OF IMMUNOLOGY,2016,197(12):4736-4749.
APA Liu, Xing,Cai, Xiaolian,Zhang, Dawei,Xu, Chenxi,&Xiao, Wuhan.(2016).Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7.JOURNAL OF IMMUNOLOGY,197(12),4736-4749.
MLA Liu, Xing,et al."Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7".JOURNAL OF IMMUNOLOGY 197.12(2016):4736-4749.
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