Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1 alpha,25(OH)(2)D-3
Peng, Xuyan1,2; Shang, Guohui1,2; Wang, Wenqing3,4; Chen, Xiaowen1,2; Lou, Qiyong1; Zhai, Gang1; Li, Dongliang5; Du, Zhenyu5; Ye, Yali4; Jin, Xia1; He, Jiangyan1; Zhang, Yi3,4; Yin, Zhan1
2017-05-16
Source PublicationCELL REPORTS
ISSN2211-1247
Volume19Issue:7Pages:1444-1455
Abstract1 alpha,25(OH)(2)D-3 (vitamin D-3) is crucial for mineral homeostasis in mammals, but the precise effects of 1 alpha,25(OH)(2)D-3 in adipose tissue remain to be clarified in vivo. The initial 25-hydroxylation is catalyzed by liver microsomal cytochrome P450 2R1 (CYP2R1), which is conserved in vertebrates. To probe the physiological function(s) of 1 alpha,25(OH)(2)D-3 in teleosts, we generated two independent cyp2r1-deficient zebrafish lines. These mutants exhibit retarded growth and increased obesity, especially in the visceral adipose tissue (VAT). These defects could be rescued with 25(OH)D-3 treatments. ChIP-PCR analyses demonstrated that pgc1a is the target of the vitamin D receptor in the liver and VAT of zebrafish. Significantly decreased protein levels of Pgc1a, impaired mitochondrial biogenesis, and free fatty acid oxidation are also observed in the cyp2r1 mutant VAT. Our results demonstrate that regulation of 1 alpha,25(OH)(2)D-3 during lipid metabolism occurs through the regulation of Pgc1a for mitochondrial biogenesis and oxidative metabolism within zebrafish VAT.
SubtypeArticle
DOI10.1016/j.celrep.2017.04.066
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(31530077) ; National Natural Science Foundation of China(31530077) ; National Basic Research Program of China (973 Program)(2014CB138602) ; National Basic Research Program of China (973 Program)(2014CB138602) ; Pilot Program A Project from the Chinese Academy of Sciences(XDA08010405) ; Pilot Program A Project from the Chinese Academy of Sciences(XDA08010405) ; National Natural Science Foundation of China(31530077) ; National Natural Science Foundation of China(31530077) ; National Basic Research Program of China (973 Program)(2014CB138602) ; National Basic Research Program of China (973 Program)(2014CB138602) ; Pilot Program A Project from the Chinese Academy of Sciences(XDA08010405) ; Pilot Program A Project from the Chinese Academy of Sciences(XDA08010405)
Language英语
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS KeywordVITAMIN-D-RECEPTOR ; DIET-INDUCED OBESITY ; DANIO-RERIO ; IN-VIVO ; EXPRESSION ; METAANALYSIS ; METABOLISM ; CELLS ; ADIPOGENESIS ; PERSPECTIVES
WOS IDWOS:000402125100015
Funding OrganizationNational Natural Science Foundation of China(31530077) ; National Natural Science Foundation of China(31530077) ; National Basic Research Program of China (973 Program)(2014CB138602) ; National Basic Research Program of China (973 Program)(2014CB138602) ; Pilot Program A Project from the Chinese Academy of Sciences(XDA08010405) ; Pilot Program A Project from the Chinese Academy of Sciences(XDA08010405) ; National Natural Science Foundation of China(31530077) ; National Natural Science Foundation of China(31530077) ; National Basic Research Program of China (973 Program)(2014CB138602) ; National Basic Research Program of China (973 Program)(2014CB138602) ; Pilot Program A Project from the Chinese Academy of Sciences(XDA08010405) ; Pilot Program A Project from the Chinese Academy of Sciences(XDA08010405)
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Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/31894
Collection藻类生物学及应用研究中心_水生生物分子与细胞生物学研究中心
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.ABLife Inc, Ctr Genome Anal, Wuhan 430075, Peoples R China
4.ABLife Inc, Lab Genome Regulat & Human Hlth, Wuhan 430075, Peoples R China
5.East China Normal Univ, Sch Life Sci, Lab Aquaculture Nutr & Environm Hlth, Shanghai 200241, Peoples R China
Recommended Citation
GB/T 7714
Peng, Xuyan,Shang, Guohui,Wang, Wenqing,et al. Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1 alpha,25(OH)(2)D-3[J]. CELL REPORTS,2017,19(7):1444-1455.
APA Peng, Xuyan.,Shang, Guohui.,Wang, Wenqing.,Chen, Xiaowen.,Lou, Qiyong.,...&Yin, Zhan.(2017).Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1 alpha,25(OH)(2)D-3.CELL REPORTS,19(7),1444-1455.
MLA Peng, Xuyan,et al."Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1 alpha,25(OH)(2)D-3".CELL REPORTS 19.7(2017):1444-1455.
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