Two type II IFN members, IFN-gamma and IFN-gamma related (rel), regulate differentially IRF1 and IRF11 in zebrafish | |
Ruan, Bai Ye1,2; Chen, Shan Nan1; Hou, Jing1; Huang, Bei3; Laghari, Zubair Ahmed1; Li, Li1; Nie, Pin1 | |
2017-06-01 | |
Source Publication | FISH & SHELLFISH IMMUNOLOGY
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ISSN | 1050-4648 |
Volume | 65Issue:1Pages:103-110 |
Abstract | Two members of type II IFNs have been identified in fish, i.e. an IFN-gamma gene as in other vertebrates and a unique IFN-gamma related (IFN-gamma rel) gene being solely present in fish. However, the signalling pathways involved in the down-stream signalling of type II IFNs in fish remains poorly described. In this study, the type II IFNs mediated IRF1 was investigated in zebrafish, and the true homologous gene of mammalian IRF1 in fish was revealed despite the report of so-called IRF1a and IRF1b in zebrafish. As revealed in overexpression analysis, zebrafish IFN-gamma had a higher induction ability than IFN-gamma rel in relation with the expression of IRF1. IFN-gamma stimulated the expression level of STAT1a and also STAT1b, but they had opposite trends with the increase of time; enhancement of STAT1a waned after 12 h post injection of plasmids; whereas STAT1b expression increased continuously. Zebrafish IRF1 gene promoter contained several putative transcription factor binding sites, including GAS and NF-kappa B motifs. Luciferase assay revealed that the GAS site was essential in the IFN-gamma triggered IRF1 expression. In contrast, IRF11 contained neither GAS nor NF-kappa B elements, and did not respond to IFN-gamma induction. It is considered that STAT1a and STAT1b are structurally and functionally similar to STAT1 alpha and STAT1 beta in mammal respectively, and that IRF11, although used to be nominated as IRF1a, is not the orthologue of mammalian IRF1, but IRF1b in zebrafish should be the orthologue. (C) 2017 Elsevier Ltd. All rights reserved. |
Keyword | Zebrafish Type II interferon IRF1 IRF11 GAS motif Signalling pathway |
DOI | 10.1016/j.fsi.2017.03.054 |
Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
Indexed By | SCI |
Language | 英语 |
Funding Project | National Natural Science Foundation of China[31320103913] ; National Natural Science Foundation of China[31402329] |
WOS Research Area | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
WOS Subject | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
WOS ID | WOS:000402943200013 |
WOS Keyword | TROUT ONCORHYNCHUS-MYKISS ; CARP CTENOPHARYNGODON-IDELLA ; CARASSIUS-AURATUS L. ; INTERFERON-GAMMA ; MOLECULAR CHARACTERIZATION ; EXPRESSION ANALYSIS ; POSITIVE REGULATOR ; FISH ; GENES ; IDENTIFICATION |
Publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ihb.ac.cn/handle/342005/31850 |
Collection | 鱼类生物学及渔业生物技术研究中心_期刊论文 |
Corresponding Author | Nie, Pin |
Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China 2.Univ Chinese Acad Sci, Beijing 10049, Peoples R China 3.Jimei Univ, Coll Fisheries, Xiamen 361021, Fujian Province, Peoples R China |
Recommended Citation GB/T 7714 | Ruan, Bai Ye,Chen, Shan Nan,Hou, Jing,et al. Two type II IFN members, IFN-gamma and IFN-gamma related (rel), regulate differentially IRF1 and IRF11 in zebrafish[J]. FISH & SHELLFISH IMMUNOLOGY,2017,65(1):103-110. |
APA | Ruan, Bai Ye.,Chen, Shan Nan.,Hou, Jing.,Huang, Bei.,Laghari, Zubair Ahmed.,...&Nie, Pin.(2017).Two type II IFN members, IFN-gamma and IFN-gamma related (rel), regulate differentially IRF1 and IRF11 in zebrafish.FISH & SHELLFISH IMMUNOLOGY,65(1),103-110. |
MLA | Ruan, Bai Ye,et al."Two type II IFN members, IFN-gamma and IFN-gamma related (rel), regulate differentially IRF1 and IRF11 in zebrafish".FISH & SHELLFISH IMMUNOLOGY 65.1(2017):103-110. |
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