IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Two type II IFN members, IFN-gamma and IFN-gamma related (rel), regulate differentially IRF1 and IRF11 in zebrafish
Ruan, Bai Ye1,2; Chen, Shan Nan1; Hou, Jing1; Huang, Bei3; Laghari, Zubair Ahmed1; Li, Li1; Nie, Pin1
2017-06-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume65Issue:1Pages:103-110
Abstract

Two members of type II IFNs have been identified in fish, i.e. an IFN-gamma gene as in other vertebrates and a unique IFN-gamma related (IFN-gamma rel) gene being solely present in fish. However, the signalling pathways involved in the down-stream signalling of type II IFNs in fish remains poorly described. In this study, the type II IFNs mediated IRF1 was investigated in zebrafish, and the true homologous gene of mammalian IRF1 in fish was revealed despite the report of so-called IRF1a and IRF1b in zebrafish. As revealed in overexpression analysis, zebrafish IFN-gamma had a higher induction ability than IFN-gamma rel in relation with the expression of IRF1. IFN-gamma stimulated the expression level of STAT1a and also STAT1b, but they had opposite trends with the increase of time; enhancement of STAT1a waned after 12 h post injection of plasmids; whereas STAT1b expression increased continuously. Zebrafish IRF1 gene promoter contained several putative transcription factor binding sites, including GAS and NF-kappa B motifs. Luciferase assay revealed that the GAS site was essential in the IFN-gamma triggered IRF1 expression. In contrast, IRF11 contained neither GAS nor NF-kappa B elements, and did not respond to IFN-gamma induction. It is considered that STAT1a and STAT1b are structurally and functionally similar to STAT1 alpha and STAT1 beta in mammal respectively, and that IRF11, although used to be nominated as IRF1a, is not the orthologue of mammalian IRF1, but IRF1b in zebrafish should be the orthologue. (C) 2017 Elsevier Ltd. All rights reserved.

KeywordZebrafish Type II interferon IRF1 IRF11 GAS motif Signalling pathway
DOI10.1016/j.fsi.2017.03.054
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31320103913] ; National Natural Science Foundation of China[31402329]
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000402943200013
WOS KeywordTROUT ONCORHYNCHUS-MYKISS ; CARP CTENOPHARYNGODON-IDELLA ; CARASSIUS-AURATUS L. ; INTERFERON-GAMMA ; MOLECULAR CHARACTERIZATION ; EXPRESSION ANALYSIS ; POSITIVE REGULATOR ; FISH ; GENES ; IDENTIFICATION
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/31850
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorNie, Pin
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China
2.Univ Chinese Acad Sci, Beijing 10049, Peoples R China
3.Jimei Univ, Coll Fisheries, Xiamen 361021, Fujian Province, Peoples R China
Recommended Citation
GB/T 7714
Ruan, Bai Ye,Chen, Shan Nan,Hou, Jing,et al. Two type II IFN members, IFN-gamma and IFN-gamma related (rel), regulate differentially IRF1 and IRF11 in zebrafish[J]. FISH & SHELLFISH IMMUNOLOGY,2017,65(1):103-110.
APA Ruan, Bai Ye.,Chen, Shan Nan.,Hou, Jing.,Huang, Bei.,Laghari, Zubair Ahmed.,...&Nie, Pin.(2017).Two type II IFN members, IFN-gamma and IFN-gamma related (rel), regulate differentially IRF1 and IRF11 in zebrafish.FISH & SHELLFISH IMMUNOLOGY,65(1),103-110.
MLA Ruan, Bai Ye,et al."Two type II IFN members, IFN-gamma and IFN-gamma related (rel), regulate differentially IRF1 and IRF11 in zebrafish".FISH & SHELLFISH IMMUNOLOGY 65.1(2017):103-110.
Files in This Item: Download All
File Name/Size DocType Version Access License
1-s2.0-S105046481730(1688KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ruan, Bai Ye]'s Articles
[Chen, Shan Nan]'s Articles
[Hou, Jing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ruan, Bai Ye]'s Articles
[Chen, Shan Nan]'s Articles
[Hou, Jing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ruan, Bai Ye]'s Articles
[Chen, Shan Nan]'s Articles
[Hou, Jing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 1-s2.0-S1050464817301821-main.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.