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Neurodevelopmental toxicity assessments of alkyl phenanthrene and Dechlorane Plus co-exposure in zebrafish
Chen, Xiangping1,2; Chen, Yuanhong3; Huang, Changjiang3; Dong, Qiaoxiang3,4,5; Roper, Courtney6,7; Tanguay, Rorbet L.6,7; Zhu, Yaxian8; Zhang, Yong1
2019-09-30
Source PublicationECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN0147-6513
Volume180Issue:1Pages:762-769
Abstract

Alkyl phenanthrene (A-Phen) and Dechlorane Plus (DP) are ubiquitous environmental pollutants that widely coexist in the environment. It has been established that both A-Phen and DP elicit neurotoxicity, but the potential interactive toxicity of these contaminants is not well-known. To determine whether a mixture of A-Phen and DP would exhibit interactive effects on neurodevelopment, we co-exposed 3-methylphenanthrene (3-MP), a representative of A-Phen, with DP. Our results illustrated that exposure to 5 or 20 mu g/L 3-MP alone or in combination with 60 mu g/L DP caused neurobehavioral anomalies in zebrafish. In accordance with the behavioral deficits, 3-MP alone or co-exposed with DP significantly decreased axonal growth of secondary motoneurons, altered intracellular Ca2+ homeostasis and induced cell apoptosis in the muscle of zebrafish. Additionally, 3-MP alone or co-exposed with DP significantly increased reactive oxygen species (ROS) and the mRNA levels of apoptosis-related genes. These findings indicate that 3-MP alone or co-exposed with DP induces neurobehavioral deficits through the combined effects on neuronal connectivity and muscle function. Chemical analysis revealed significant increases in 3-MP and DP bioaccumulation in zebrafish co-exposed with 3-MP and DP. Elevated bioaccumulation resulting from mixture exposure may represent a significant contribution of the synergistic effects observed in combined chemical exposure.

KeywordAlkyl phenanthrene Dechlorane plus Co-exposure Neurodevelopmental toxicity Synergistic effect
DOI10.1016/j.ecoenv.2019.05.066
Funding OrganizationNatural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of China[21577110] ; Natural Science Foundation of China[21627814] ; National Institutes of Health[T32 ES007060]
WOS Research AreaEnvironmental Sciences & Ecology ; Toxicology
WOS SubjectEnvironmental Sciences ; Toxicology
WOS IDWOS:000473836100086
WOS KeywordAXONAL GROWTH ; MOTOR BEHAVIOR ; DECABROMODIPHENYL ETHER ; EXPOSURE ; PAHS ; PRECIPITATION ; CHLORPYRIFOS ; MUSCULATURE ; RESPONSES ; MIXTURES
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Funding OrganizationNatural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/31683
Collection其他_期刊论文
Corresponding AuthorZhang, Yong
Affiliation1.Xiamen Univ, Coll Environm & Ecol, State Key Lab Marine Environm Sci China, Xiamen 361102, Fujian, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
3.Wenzhou Med Univ, Inst Environm Safety & Human Hlth, Wenzhou 325035, Peoples R China
4.Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou 325035, Peoples R China
5.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325035, Peoples R China
6.Oregon State Univ, Environm & Mol Toxicol, Sinnhuber Aquat Res Lab, Corvallis, OR 97333 USA
7.Oregon State Univ, Environm Hlth Sci Ctr, Corvallis, OR 97333 USA
8.Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Fujian, Peoples R China
Recommended Citation
GB/T 7714
Chen, Xiangping,Chen, Yuanhong,Huang, Changjiang,et al. Neurodevelopmental toxicity assessments of alkyl phenanthrene and Dechlorane Plus co-exposure in zebrafish[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2019,180(1):762-769.
APA Chen, Xiangping.,Chen, Yuanhong.,Huang, Changjiang.,Dong, Qiaoxiang.,Roper, Courtney.,...&Zhang, Yong.(2019).Neurodevelopmental toxicity assessments of alkyl phenanthrene and Dechlorane Plus co-exposure in zebrafish.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,180(1),762-769.
MLA Chen, Xiangping,et al."Neurodevelopmental toxicity assessments of alkyl phenanthrene and Dechlorane Plus co-exposure in zebrafish".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 180.1(2019):762-769.
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