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Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia
Bi, Jianling1; Hu, Bo1; Wang, Jing1; Liu, Xing1; Zheng, Jinsong1; Wang, Ding1; Xiao, Wuhan1,2
2017-06-27
Source PublicationONCOTARGET
ISSN1949-2553
Volume8Issue:26Pages:42272-42287
Abstract

Aquatic mammals, such as cetaceans experience various depths, with accordingly diverse oxygenation, thus, cetaceans have developed adaptations for hypoxia, but mechanisms underlying this tolerance to low oxygen are unclear. Here we analyzed VHL and HIF-2 alpha, in the hypoxia signaling pathway. Variations in VHL are greater than HIF-2 alpha between cetaceans and terrestrial mammals, and beluga whale VHL (BW-VHL) promotes HIF-2 alpha degradation under hypoxia. BW-VHL catalyzes BW-HIF-2 alpha to form K48-linked polyubiquitin chains mainly at the lysine 429 of BW-HIF-2 alpha (K429) and induces BW-HIF-2 alpha for proteasomal degradation. W100 within BW-VHL is a key site for BW-VHL functionally and BW-VHL enhances transcriptional activity of BW-HIF-2 alpha under hypoxia. Our data therefore reveal that BW-VHL has a unique function that may contribute to hypoxic adaptation.

Keywordbeluga whale cetaceans hypoxia HIF-2 alpha VHL
DOI10.18632/oncotarget.15038
Funding OrganizationCAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC
Indexed BySCI
Language英语
Funding ProjectCAS Major Scientific and Technological Project[XDA08010208] ; NSFC[31461163003] ; NSFC[91631102] ; NSFC[31430080]
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000405493400045
WOS KeywordTUMOR-SUPPRESSOR PROTEIN ; HIGH-ALTITUDE ADAPTATION ; BAIJI LIPOTES-VEXILLIFER ; DELPHINAPTERUS-LEUCAS ; HIF-ALPHA ; MOLE-RAT ; FINLESS PORPOISE ; DIVING BEHAVIOR ; YANGTZE-RIVER ; WHITE WHALES
PublisherIMPACT JOURNALS LLC
Funding OrganizationCAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/31445
Collection水环境工程研究中心_期刊论文
Corresponding AuthorWang, Ding; Xiao, Wuhan
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Bi, Jianling,Hu, Bo,Wang, Jing,et al. Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia[J]. ONCOTARGET,2017,8(26):42272-42287.
APA Bi, Jianling.,Hu, Bo.,Wang, Jing.,Liu, Xing.,Zheng, Jinsong.,...&Xiao, Wuhan.(2017).Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia.ONCOTARGET,8(26),42272-42287.
MLA Bi, Jianling,et al."Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia".ONCOTARGET 8.26(2017):42272-42287.
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