Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia | |
Bi, Jianling1; Hu, Bo1; Wang, Jing1; Liu, Xing1; Zheng, Jinsong1; Wang, Ding1; Xiao, Wuhan1,2 | |
2017-06-27 | |
Source Publication | ONCOTARGET
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ISSN | 1949-2553 |
Volume | 8Issue:26Pages:42272-42287 |
Abstract | Aquatic mammals, such as cetaceans experience various depths, with accordingly diverse oxygenation, thus, cetaceans have developed adaptations for hypoxia, but mechanisms underlying this tolerance to low oxygen are unclear. Here we analyzed VHL and HIF-2 alpha, in the hypoxia signaling pathway. Variations in VHL are greater than HIF-2 alpha between cetaceans and terrestrial mammals, and beluga whale VHL (BW-VHL) promotes HIF-2 alpha degradation under hypoxia. BW-VHL catalyzes BW-HIF-2 alpha to form K48-linked polyubiquitin chains mainly at the lysine 429 of BW-HIF-2 alpha (K429) and induces BW-HIF-2 alpha for proteasomal degradation. W100 within BW-VHL is a key site for BW-VHL functionally and BW-VHL enhances transcriptional activity of BW-HIF-2 alpha under hypoxia. Our data therefore reveal that BW-VHL has a unique function that may contribute to hypoxic adaptation. |
Keyword | beluga whale cetaceans hypoxia HIF-2 alpha VHL |
DOI | 10.18632/oncotarget.15038 |
Funding Organization | CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC |
Indexed By | SCI |
Language | 英语 |
Funding Project | CAS Major Scientific and Technological Project[XDA08010208] ; NSFC[31461163003] ; NSFC[91631102] ; NSFC[31430080] |
WOS Research Area | Oncology ; Cell Biology |
WOS Subject | Oncology ; Cell Biology |
WOS ID | WOS:000405493400045 |
WOS Keyword | TUMOR-SUPPRESSOR PROTEIN ; HIGH-ALTITUDE ADAPTATION ; BAIJI LIPOTES-VEXILLIFER ; DELPHINAPTERUS-LEUCAS ; HIF-ALPHA ; MOLE-RAT ; FINLESS PORPOISE ; DIVING BEHAVIOR ; YANGTZE-RIVER ; WHITE WHALES |
Publisher | IMPACT JOURNALS LLC |
Funding Organization | CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ihb.ac.cn/handle/342005/31445 |
Collection | 水环境工程研究中心_期刊论文 |
Corresponding Author | Wang, Ding; Xiao, Wuhan |
Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
Recommended Citation GB/T 7714 | Bi, Jianling,Hu, Bo,Wang, Jing,et al. Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia[J]. ONCOTARGET,2017,8(26):42272-42287. |
APA | Bi, Jianling.,Hu, Bo.,Wang, Jing.,Liu, Xing.,Zheng, Jinsong.,...&Xiao, Wuhan.(2017).Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia.ONCOTARGET,8(26),42272-42287. |
MLA | Bi, Jianling,et al."Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia".ONCOTARGET 8.26(2017):42272-42287. |
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Bi-2017-Beluga whale(4051KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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